Results 71 to 80 of about 2,915 (202)

Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions

, 2018
Hyoscyamine 6β-hydroxylase (H6H) is an α-ketoglutarate dependent mononuclear nonheme iron enzyme that catalyzes C6-hydroxylation of hyoscyamine and oxidative cyclization of the resulting product to give the oxirane natural product scopolamine.
Hung-wen Liu (1279131), Yung-nan Liu (1952272), Mark W. Ruszczycky (1575478), Feng Yan (183226), Richiro Ushimaru (1674505), Wei-chen Chang (1530808)   +5 more
core   +1 more source

THE ACTION OF HYOSCYAMINE AND ITS RELIABILITY. [PDF]

The Lancet, 1878
n ...
openaire   +2 more sources

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, Volume 12, Issue 42, November 13, 2025.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

A modified QuEChERS method coupled with liquid chromatography-tandem mass spectrometry for the simultaneous detection and quantification of scopolamine, L-hyoscyamine, and sparteine residues in animal-derived food products

Journal of Advanced Research, 2019
We developed a modified Quick, Easy, Cheap, Effective, Rugged, and Safe (CEN QuEChERS) extraction method coupled with liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI+/MS-MS) to identify and quantify residues of three ...
Weijia Zheng, Kyung-Hee Yoo, Jeong-Min Choi, Da-Hee Park, Seong-Kwan Kim, Young-Sun Kang, A.M. Abd El-Aty, Ahmet Hacımüftüoğlu, Ji Hoon Jeong, Alaa El-Din Bekhit, Jae-Han Shim, Ho-Chul Shin   +11 more
doaj   +1 more source

Proteomic insights on root and tuber crops’ response to abiotic stress—A review

Crop Science, Volume 65, Issue 6, November/December 2025.
Abstract Root and tuber crops are a good source of food energy on a global scale, particularly in African and Asian nations. Nevertheless, these crops can be susceptible to abiotic stresses such as excessive heat, high salinity, drought, and nutrient deficiencies, which have detrimental effects on the physiological and metabolic processes of the plants,
L. E. Siviya, S. Figlan, S. M. Laurie, M. E. Rauwane   +3 more
wiley   +1 more source

Assessment of Morphological and Tropane Alkaloids Diversity among some Henbane (Hyoscyamus niger L.) Populations

Journal of Medicinal Plants, 2019
Background: Black henbane with the scientific name of Hyoscyamus niger which has a wide geographic distribution, is considered as one the most important species for tropane alkaloids extraction.
M Ghorbanpour, H Salehi-arjmand, M Hatami, N Hosseini   +3 more
doaj  

Regioselectivity of hyoscyamine 6 beta hydroxylase catalysed hydroxylation as revealed by high resolution structural information and QM MM calculations

, 2020
Hyoscyamine 6β-hydroxylase (H6H) is a bifunctional non-heme 2-oxoglutarate/Fe2+-dependent dioxygenase that catalyzes the two final steps in the biosynthesis of scopolamine.
Wojdyla, Z., Weiss, Manfred, Kluza, A., Minor, W., Kluza, Anna, Borowski, Tomasz, Wojdyla, Zuzanna, Minor, Wladek, Weiss, Manfred S., Mrugala, B., Porebski, P.J., Kurpiewska, Katarzyna, Minor, Władek, Niedzialkowska, Ewa, Kurpiewska, K., Niedzialkowska, E., Borowski, T., Porebski, Przemyslaw J., Mrugała, Beata, Porębski, Przemysław J., Wojdyła, Zuzanna, Weiss, M.S., Niedziałkowska, Ewa, Mrugala, Beata   +23 more
core   +1 more source

Quantitative analysis of 1-hyoscyamine in Hyoscyamus reticulatus L. by GC-MS

, 2003
The hyoscyamine content of leaves and root samples of Hyoscyamus reticulatus L. from Bulamk, Mus in east Anatolia, Turkey, was determined by capillary GC-MIS to be 0.036 +/- 0.004% in the leaves and 0.056 +/- 0.011% in the roots as the predominant ...
Ceyhan, T, Altun, L, Sayar, E, Cevheroglu, S, Yetkin, Y, Kartal, M, Kurucu, S   +6 more
core   +2 more sources

Changes of Tropane Alkaloids in Black Henbane (Hyoscyamus niger L.) in Response to Different Types of Nitrogenous Fertilizers

Journal of Medicinal Plants, 2017
Background: Since alkaloids are nitrogenous compounds, the availability of nitrogen (N) is expected to play an important role in the biosynthesis and accumulation of alkaloids in plants.
N Banani, A Mehrafarin, SM Hosseini Mazinani   +2 more
doaj  

Enhanced secretion of tropane alkaloids in Nicotiana tabacum hairy roots expressing heterologous hyoscyamine-6β-hydroxylase

, 2005
Hyoscyamine-6β-hydroxylase (H6H; EC 1.14.11.11) catalyses oxidative reactions in the biosynthetic pathway leading from hyoscyamine to the more pharmaceutically valuable tropane alkaloid scopolamine.
Oksman-Caldentey, Kirsi-Marja; id_orcid, Piñol, M. Teresa, Häkkinen, Suvi T.; id_orcid, Palazón, Javier, Cusidó, Rosa M., Moyano, Elisabeth   +5 more
core   +1 more source