Results 91 to 100 of about 2,915 (202)

Isolation and identification of Hyoscyamus insanus alkaloids

Journal of Medicinal Plants, 2003
Hyoscyamus is one of the important genus in Solanaceae which distribution of some of its species is restricted to Iran and some of the neighboring countries. The main medicinal substances in this plant are alkaloids (tropane alkaloids). One of Hyoscyamus
M Tafaghodi, M Hasanzadeh khayat, M Rahimizadeh   +2 more
doaj  

De Novo Synthesis of Anticholinergic Hyoscyamine and Scopolamine in Nicotiana benthamiana Based on Elucidating Tropane Alkaloid Biosynthetic Pathway of Anisodus luridus

Agronomy
Anisodus luridus, a perennial herb belonging to the genus Anisodus of the Solanaceae family, is an important Tibetan medicinal plant that produces pharmaceutical tropane alkaloids (TAs) including hyoscyamine and scopolamine. Its high yield of hyoscyamine
Mengling Wen, Junlan Zeng, Fei Qiu, Fangyuan Zhang, Zhihua Liao   +4 more
doaj   +1 more source

Poisoned after Dinner: Dolma with Datura Stramonium

Turkish Journal of Emergency Medicine, 2015
SUMMARY: Datura stramonium, which is also known as Thorn Apple or Jimson Weed, is an alkaloid containing plant that is entirely toxic. The active toxic constituents of the plant are atropine, scopolamine and hyoscyamine.
Nezihat Rana DISEL, Mustafa YILMAZ, Zeynep KEKEC, Meryem KARANLIK   +3 more
doaj   +1 more source

Biosynthesis of Hyoscyamine involves an Intramolecular Rearrangement of Littorine

, 1994
The direct biosynthesis of hyoscyamine 3 from littorine 1 has been demonstrated by feeding (RS)-phenyl [ 1 ,3-13C,] lactoyl [methyl-*H,]tropine (littorine 13) to transformed root cultures of Datura stramonium.
Na Peter Bachrnanna, Richard J Robins, Jack G Woolleyb   +2 more
core  

Scopolamine and hyoscyamine production by hairy root cultures of Brugmansia candida: Influence of calcium chloride, hemicellulase and theophylline [PDF]

, 2000
CaCl2 (50 mM) and hemicellulase (0.5 U mg-1) increased the intracellular accumulation (60-250%), release (60-200%) and production (45-200%) of hyoscyamine and scopolamine in hairy roots of Brugmansia candida.
Pitta Alvarez, Sandra Irene, Spollansky, T. C., Giulietti, Ana Maria   +2 more
core   +1 more source

Development of a CRISPR/Cas9 Platform in Datura inoxia for Disrupting Tropane Alkaloid Biosynthesis to Generate Non-Toxic Germplasm

Horticulturae
Datura species are valued ornamentals but contain toxic tropane alkaloids (TAs) like hyoscyamine and scopolamine, which restrict their safe horticultural use. To address this, we developed a genome editing platform in Datura inoxia for creating non-toxic
Xianfang Zou, Tianxing Yuan, Yuxin Zhang, Xiaohan Zhang, Guoqing Niu, Yulong Guo   +5 more
doaj   +1 more source

Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea – tuning the scopolamine production

, 2018
Using a stabilizing small ubiquitin like modifier (SUMO) fusion, a new homologue of hyoscyamine-6β-hydroxylase from Brugmansia sanguinea (BsH6H) boosts scopolamine production.
Dae-Kun Ro, Conrad Fischer, Marco J. van Belkum, Moonhyuk Kwon, John C. Vederas   +4 more
core   +1 more source

An UPLC/Q-TOF-MS method for the detection of toxic substances in Datura stramonium L.

Zhongguo shipin weisheng zazhi
ObjectiveTo establish an ultra-high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry（UPLC/Q-TOF-MS）method for rapid screening of toxic substances in Datura stramonium L..MethodsAfter the samples were extracted by
ZHOU Ronggui, KOU Jinchan, ZHANG Yonghong, LIN Ji   +3 more
doaj   +1 more source

Analytical considerations for the successful evaluation of hyoscyamine biotransformation into 6b-hydroxyhyoscyamine and scopolamine [PDF]

, 2012
Hyoscyamine, 6B-hydroxyhyoscyamine and scopolamine are anticholinergic agents that be-long to the tropane alkaloids, a pharmacological important group of secondary metabolites. Hyoscyamine and scopolamine were historically used in medicine. Additionally,
Rodriguez Talou, Julian, Giulietti, Ana Maria, Cardillo, Alejandra Beatriz   +2 more
core  

Diversité morphologique et teneur en hyoscyamine/scopolamine de douze provenances algériennes de Datura stramonium L.

, 2011
Morphological diversity and hyoscyamine/scopolamine contents in twelve Algerian samples of Datura stramonium L. of different origin. Morphological diversity was estimated on 15 phenotypic characters of Datura stramonium from twelve samples of different
Khelifi-Slaoui, Majda, Amdoun, Ryad, Khelifi, Lakhdar, Bakiri, Nouara, Derridj, Arezki, Morsli, Abdelkader   +5 more
core   +1 more source