Results 21 to 30 of about 2,125 (176)
In December 2022 a large outbreak of anti-cholinergic toxidrome was reported in Australia associated with contamination of baby spinach leaves with Datura stramonium. Over 100 individuals around Australia experienced symptoms consistent with intoxication
David Heslop
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ObjectiveScreening bio-samples from a food poisoning event based on ultra-high-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF MS), and to provide strategies and references for patient treatment as well as the ...
GUO Qiaozhen +4 more
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Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants
Hyoscyamine and scopolamine, belonging to medicinal tropane alkaloids (MTAs), are potent anticholinergic drugs. Their industrial production relies on medicinal plants, but the levels of the two alkaloids are very low in planta.
Haiyue Gong +5 more
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Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium [PDF]
The alkaloid extract of datura stramonium (rich of atropine, hyoscyamine, scopolamine) is used to evaluate its effect on the central nervous system in rats (locomotion, anxiety).
Didou Latifa +5 more
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Application of Metabolic Engineering to the Production of Scopolamine
Scopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular
Mohammad Hossein Mirjalili +3 more
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Enhancement of Growth and Alkaloids Accumulation in Hyoscyamus muticus L. Callus Cultures by High Salt Concentration [PDF]
The effect of different concentrations of NaCl (6, 8 and 10 dS/m) on growth and alkaloids production in 21 days-old callus of Egyptian henbane (Hyoscyamu muticus L.) was studied.
Akram Abuseidah +5 more
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Reversible acetylcholinesterase inhibitors are used as first-line treatment for myasthenia gravis. They improve symptoms by increasing concentration of acetylcholine at the neuromuscular junction and stimulating nicotinic receptors.
Mohammad Saud Khan +5 more
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