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Whipple's disease is a systemic chronic bacterial infection caused by Tropheryma whipplei, a gram‐positive bacillus. T. whipplei infection in the small intestine often causes malabsorption and is often accompanied by gastrointestinal symptoms such as ...
Yujiro Henmi +9 more
doaj +1 more source
Pulmonary parenchymal involvement caused by Tropheryma whipplei
We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected ...
Zhang Wen Mei, Xu Ling
doaj +1 more source
Background: Celiac disease (CD) is one of the most common disorders, resulting from both environmental (gluten) and genetic factors. The clinical features of the Iranian CD are still unknown and there is insufficient information about the atypical ...
Mostafa Sayyadi +3 more
doaj +1 more source
A Case of Whipple's Disease Related Infectious Endocarditis
Whipple's disease is caused by Tropheryma whipplei and is known to have protean clinical presentation which could be influenced by patient's immunologic and genetic features.
N. V. Ivanova +4 more
doaj +1 more source
Cultivation of \u3cem\u3eTropheryma whipplei\u3c/em\u3e from Cerebrospinal Fluid [PDF]
Whipple disease (WD) is a systemic disorder caused by the bacterium Tropheryma whipplei. Since the recognition of a bacterial etiology in 1961, many attempts have been made to cultivate this bacterium in vitro.
Fredricks, David N. +5 more
core +5 more sources
Valvular Endocarditis and Biventricular Heart Failure in the Setting of Tropheryma whipplei Disease [PDF]
Whipple disease is a rare systemic illness associated with weight loss, diarrhea, and arthralgia. Asymptomatic carriage is common, but the disease can be complicated by cardiac involvement and may result in culture-negative endocarditis.
Defne Gunes Ergi, MD +5 more
doaj +1 more source
Service evaluation to establish the sensitivity, specificity and additional value of broad-range 16S rDNA PCR for the diagnosis of infective endocarditis from resected endocardial material in patients from eight UK and Ireland hospitals [PDF]
Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain ...
Alshafi, K +8 more
core +1 more source
Constrictive pleuropericarditis: a dominant clinical manifestation in Whipple’s disease [PDF]
Background: Whipple’s disease is a rare, multisystemic, chronic infectious disease which classically presents as a wasting illness characterized by polyarthralgia, diarrhea, fever, and lymphadenopathy. Pleuropericardial involvement is a common pathologic
Alan N Baer +5 more
core +1 more source
Abstract Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD ...
Richard Lathe +30 more
wiley +1 more source
Tropheryma whipplei, the agent of Whipple's disease, inhibits phago-lysosome biogenesis to create a suitable niche for its survival and replication in macrophages. To understand the mechanism by which it subverts phagosome maturation, we used biochemical
Giovanna Mottola +6 more
doaj +1 more source

