Protein Kinase C Regulates Meiosis in Mammalian Oocytes
Protein kinase C (PKC) participates in the regulation of mammalian oocyte meiosis. PKC is involved in meiosis resumption in prophase I and in the stabilization of meiosis I and meiosis II spindles. PKC stimulates the maturation‐promoting factor during fertilization and stabilizes the mitotic spindle during early embryo development. ABSTRACT The protein
Jaroslav Kalous +2 more
wiley +1 more source
Exposure to polystyrene nanoparticles induce disruption of mitochondrial homeostasis and impairs trophoblast cell invasion and migration via MDM2/ROCK1 pathway. [PDF]
Hao D, Ma T, Li X, Gao F.
europepmc +1 more source
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication
Origin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Victoria Frisbie, Franziska Bleichert
wiley +1 more source
Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway. [PDF]
Yi S +14 more
europepmc +1 more source
Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells
In this study, the authors identified regions with enhancer activity in the CHO cell genome using genome‐wide and targeted STARR‐seq. The analysis revealed thousands of newly identified enhancer sequences, where some of the most active sequences could drive transgene expression at levels similar to or higher than strong viral enhancers.
María Santos +9 more
wiley +1 more source
TCF7L2 is essential for the differentiation and invasive function of human extravillous trophoblast. [PDF]
Salamah J +4 more
europepmc +1 more source
Vulnerability of primitive human placental trophoblast to Zika virus
M. Sheridan +13 more
semanticscholar +1 more source
ABSTRACT The importance of co‐infections is not yet completely understood, and the impact and direction of their effects vary considerably. This study aimed to evaluate the role of total saline extract (TS) and excretory/secretory (ES) products of Strongyloides venezuelensis filarioid larvae on a maternal‐interface cell model during Toxoplasma gondii ...
Fabíola Teixeira Alves +8 more
wiley +1 more source
The molecular pathogenesis of placenta accreta spectrum disorder and its clinical applications. [PDF]
Zhao M, Sun L, Wu D.
europepmc +1 more source

