Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms [PDF]
Translational Oncology, 2021 The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely ...
G. Frega +5 more
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Progress of immunotherapies in gestational trophoblastic neoplasms. [PDF]
J Cancer Res Clin Oncol, 2023 Different from other malignant gynecologic tumors, gestational trophoblastic neoplasms (GTNs) exhibit an exceptionally high cure rate primarily through chemotherapeutic interventions. However, there exists a small subset of refractory GTNs that do not respond to conventional chemotherapies.
Wang T +6 more
europepmc +3 more sources
Gestational Trophoblastic Disease: Diagnostic and Therapeutic Updates in Light of Recent Evidence: A Literature Review [PDF]
MedicinaBackground/objectives: Gestational trophoblastic diseases (GTDs) are rare premalignant and malignant conditions characterized by abnormal proliferation of trophoblastic tissue. They are often asymptomatic but may present with vaginal bleeding.
Giuseppe Gullo +9 more
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Machine learning-driven survival prediction in gestational trophoblastic neoplasms: a focus on PSTT and ETT prognosis [PDF]
Frontiers in OncologyIntroductionThe clinicopathological characteristics and prognosis of placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) have not been well summarized.
Sakhr Alshwayyat +6 more
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Diagnostic pitfall in primary cervical gestational choriocarcinoma: a case report [PDF]
Frontiers in OncologyChoriocarcinoma belongs to a group of highly aggressive malignant gestational trophoblastic neoplasms. Choriocarcinoma is classified into two types based on the origin: a gestational type that arises following a normal or abnormal pregnancy and a non ...
Jiayu Shi, Ping Chen
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A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. [PDF]
PLoS ONE, 2014 As epithelioid trophoblastic tumor (ETT) shares similar clinical features with other gestational trophoblastic neoplasms (GTNs), it is likely to be clinically misdiagnosed and subsequently treated in an improper way.
Jiale Qin +9 more
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Laparoscopic hysterectomy as a treatment modality for gestational trophoblastic neoplasia: A report of two cases [PDF]
Vojnosanitetski Pregled, 2022 Introduction. Measuring the serum levels of human chorionic gonadotropin beta isoform (β-hCG) remains a crucial marker for diagnosing gestational trophoblastic neoplasms (GTNs). Choriocarcinoma is commonly diagnosed due to extremely high levels of β-hCG,
Jokanović Predrag, Rakić Aleksandar
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Is There a Role for Surgery in the Management of Gestational Trophoblastic Neoplasia? [PDF]
Middle East Journal of Cancer, 2022 Background: Gestational trophoblastic diseases are treated with chemotherapy, but some patients are resistant to it and require surgeries. The role of surgery in the management of these patients is not clearly defined.
Malihe Hasanzadeh +3 more
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Swiss Medical Weekly, 2021 AIMS OF THE STUDY The European Society of Medical Oncology (ESMO) recommends that countries should have reference centres to provide adequate diagnosis and treatment of gestational trophoblastic disease.
Aurore Fehlmann +12 more
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Frontiers in Oncology, 2022 Gestational trophoblastic neoplasias (GTN) are malignant neoplasms that occur in pregnant or recently pregnant women. Choriocarcinoma (CCA) is a highly aggressive and rare GTN, and cases outside the female genital tract are commonly seen as secondary ...
Filipa Ferreira da Silva +5 more
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