Results 101 to 110 of about 8,177 (250)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, Volume 13, Issue 16, 18 March 2026.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Changing Concepts of Cancer Biology, Diagnosis and Treatment [PDF]

, 1981
Cancer is the number two killer in the United State and will probably account for some 400,000 deaths in 1982. The lung has now achieved the dubious distinction of being the most common site of cancer in men and causes the most deaths.
Taub, Robert N.
core   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Epithelioid Trophoblastic Tumor Similar to Uterine Arteriovenous Malformation: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Overview of the intraoperative and gross pathological findings of an epithelioid trophoblastic tumor mimicking uterine arteriovenous malformation. ABSTRACT Epithelioid trophoblastic tumor (ETT) is a rare subtype of gestational trophoblastic neoplasia, most commonly arising in the cervix or lower uterine segment and often associated with mildly elevated
Huihua Xiang, Xiaoxiao Feng, Shanrong Shu   +2 more
wiley   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

Uncovering the role of genetic polymorphisms in cervical insufficiency

International Journal of Gynecology &Obstetrics, Volume 172, Issue 3, Page 1335-1341, March 2026.
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi, Michail Kalinderis, Maria Chatzidimitriou, Liana Fidani   +3 more
wiley   +1 more source

Application of Multimodal Ultrasound Combined With BI‐RADS in Classification and Diagnosis of Non‐Mass Breast Lesions

Journal of Clinical Ultrasound, Volume 54, Issue 3, Page 609-617, March/April 2026.
This study demonstrates that integrating microvascular flow imaging, shear wave elastography, and contrast‐enhanced ultrasound with the BI‐RADS classification significantly improves the diagnostic accuracy for non‐mass breast lesions, offering a more reliable tool for differentiating benign from malignant findings.
Zengdi Yang, Yongyan Lyu, Yanting Yang, Cuiping Xu, Keke Zhang, Xuxu Yang, Feng Chen, Lanlan Cheng, Minglei Ren   +8 more
wiley   +1 more source

Review of potential doppler ultrasonographic findings in patients with confirmed gestational trophoblastic neoplasms [PDF]

Vojnosanitetski Pregled, 2006
Nikolić Branka, Lazić Jelena
doaj   +1 more source

RADIOTERAPY IN GESTATIONAL TROPHOBLASTIC NEOPLASM

Revista de Patologia do Tocantins, 2018
A neoplasia trofoblástica gestacional abrange um grupo de doenças que têm origem no tecido placentário, apresentando tendências distintas de invasão, podendo chegar até a metástase, que é a sua forma mais grave. É uma neoplasia curável e isto se dá devido à alta sensibilidade das dosagens seriadas de gonadotrofina coriônica humana aliada ao tratamento ...
Ribeiro, Thais Alves, Ruiz de Moraes, Fábio Roberto   +1 more
openaire   +1 more source