Results 51 to 60 of about 99,435 (247)

Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity

Biochemistry and Biophysics Reports, 2021
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT).
Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa   +7 more
doaj   +1 more source

Ovarian Intermediate Trophoblastic Tumors

, 2019
Trophoblastic neoplasms involving the ovary are uncommon and include gestational tumors, which are either metastatic from the uterus or ectopic and nongestational tumors, which include those of germ cell type/origin and somatic tumors with trophoblastic ...
Shaotiao Li, Brigitte M. Ronnett, Xing, Deyin, Ronnett, Brigitte M, Zhong, Minghao, Li, Shaotiao, Fei Ye, Minghao Zhong, Deyin Xing, Russell Vang, Vang, Russell, Ye, Fei, O\u27Malley, Michael T, Michael T. O’Malley   +13 more
core   +1 more source

Gestational trophoblastic neoplasia of intermediate trophoblasts: Epithelioid trophoblastic tumor and placental site trophoblastic tumor, a study of morphologic, immunohistochemical, and next generation sequencing

, 2023
Objective: Gestational trophoblastic tumors are very rare neoplasms. We determined the distinctive morphological, immunohistochemical, and clinical features of placental site trophoblastic tumors (PSTT) and epithelioid trophoblastic tumors (ETT) in our ...
Güler, Yeşim Gaye, Gündoğdu, Fatma, Usubütün, Alp, Güneş, Ali Can, Atalay, Fatma Öz, Kapaklı, Gözde Elif Tasar   +5 more
core   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Significance of transvaginal Doppler ultrasonography for detection of malignant gestational trophoblastic disease [PDF]

Vojnosanitetski Pregled, 2005
Transvaginal Doppler ultrasonography has an important role in detecting and confirming the gestational trophoblastic disease (GTD). It can also be helpful in early detection of the malignant cases of GTD such as the invasion and protrusion of ...
Nikolić Branka, Rakić Snežana, Pavlović Dejan, Popovac Svetlana, Lukić Relja   +4 more
doaj   +1 more source

In vitro chemosensitivity of paclitaxel and other chemotherapeutic agents in malignant gestational trophoblastic neoplasms.

, 1995
This is the first report on the ATP cell viability assay as a chemosensitivity test system for gestational trophoblastic neoplasms (GTN). We obtained chemosensitivity profiles in two established trophoblastic cell lines and four fresh tumors.
Rodriguez M, Schenk V, Sevin BU, Haller U, Schaer GN, Koechli OR, Untch M, Steren A, Perras JP   +8 more
core   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Gestational Trophoblastic Disease: Diagnostic and Therapeutic Updates in Light of Recent Evidence: A Literature Review

Medicina
Background/objectives: Gestational trophoblastic diseases (GTDs) are rare premalignant and malignant conditions characterized by abnormal proliferation of trophoblastic tissue. They are often asymptomatic but may present with vaginal bleeding.
Giuseppe Gullo, Marinì Satullo, Eleonora Conti, Silvia Ganduscio, Elena Chitoran, Zoltan Kozinszky, Karolina Kowalcze, Robert Krysiak, Valentina Billone, Gaspare Cucinella   +9 more
doaj   +1 more source

Amenorrhea and elevated βhuman chorionic gonadotropin of unknown origin: An unexpected location of choriocarcinoma

Gynecologic Oncology Reports, 2021
Choriocarcinoma is a rare malignancy originating from trophoblastic cells that is known to arise from the placenta. In this report, we describe the case of a 28-year-old female who consulted for amenorrhea and elevated βhCG mimicking a pregnancy of an ...
Ichrak Ben Abdallah, Mona Mlika, Yosra Berrazega, Nesrine Mejri, Haifa Rachdi, Houda El Benna, Nouha Daoud, Soumaya Laabidi, Faouzi Mezni, Hamouda Boussen   +9 more
doaj   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source