Results 71 to 80 of about 562,657 (215)

Seasonal Tropical Cyclone Forecasting

Tropical Cyclone Research and Review, 2019
This paper summarizes the forecast methods, outputs and skill offered by twelve agencies for seasonal tropical cyclone (TC) activity around the world.
P. Klotzbach, E. Blake, J. Camp, L. Caron, J. Chan, N. Kang, Yuriy Kuleshov, Sai‐Ming Lee, H. Murakami, M. Saunders, Y. Takaya, F. Vitart, R. Zhan   +12 more
semanticscholar   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

The impact of Neglected Tropical Diseases (NTDs) on health and wellbeing in sub-Saharan Africa (SSA): A case study of Kenya

PLoS Neglected Tropical Diseases, 2019
Neglected Tropical Diseases (NTDs) remain endemic to many regions of sub-Saharan Africa (SSA) left behind by socioeconomic progress. As such, these diseases are markers of extreme poverty and inequity that are propagated by the political, economic ...
Elizabeth A. Ochola, D. Karanja, S. Elliott   +2 more
semanticscholar   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Bond Softening and Elastic Confinement of Monolithic Dense Binary Alloys for High Volumetric Capacity of K‐Ion Battery Anodes

Angewandte Chemie, EarlyView.
Synergistically intrinsic‐extrinsic dual‐stabilization engineering to construct dense monolithic alloy architectures is proposed by integrating 2D binary alloy nanosheets into 3D elastic graphene networks. Such a dense monolithic anode achieves high volumetric and areal performance, enabling fast K+ transfer and superior structural recovery during ...
Yunyong Li, Yiru Zhou, Bingchun Wang, Xinying Wang, Lei Liu, Zhuhang Shao, Hao Wu, Zaowen Zhao, Yingqiang Wu, Xuerong Zheng, Xinwei Li, Wenwu Li, Yida Deng, Zaiping Guo, Ho Seok Park   +14 more
wiley   +2 more sources

The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016

PLoS Neglected Tropical Diseases, 2018
Background Neglected Tropical Diseases (NTDs) are important causes of morbidity, disability, and mortality among poor and vulnerable populations in several countries worldwide, including Brazil.
F. R. Martins-Melo, M. Carneiro, Alberto Novaes Ramos Junior, J. Heukelbach, A. Ribeiro, G. Werneck   +5 more
semanticscholar   +1 more source

Climate Change Agricultural Comparative Advantage and the US Trade Balance

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Current science indicates that warming and elevated atmospheric CO2 will have ambiguous results for crop productivity depending on crop type and geographic location, whereas increased heat stress makes livestock and human labor less productive.
Elizabeth A. Fraysse, Thomas W. Hertel, Roman Keeney   +2 more
wiley   +1 more source

Temperature and Farm Labor in Nigeria

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We estimate the impact of temperature shocks on the composition of farm labor in rural Nigeria using a nationally representative household panel survey. Leveraging plausibly exogenous year‐to‐year variation in growing season temperatures, we find that warmer temperatures significantly alter farm labor composition, prompting a substantial shift
Andu Berha
wiley   +1 more source