Results 41 to 50 of about 3,291,749 (241)

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Wanda Maria Błeńska and her contribution to fight against leprosy in the world

Annales Missiologici Posnanienses, 2015
The article includes biography and data on professional and social activities of Dr. Wanda Maria Błeńska (1911-2014), a high-minded person fully dedicated to medical help and humanitarian aid for the people in Africa and other countries of the world. Dr.
Andrzej Łukaszyk
doaj   +1 more source

Global Medicine, Parasites, and Tasmania

Tropical Medicine and Infectious Disease, 2020
Until the 1970s, infectious disease training in most medical schools was limited to those diseases common in the area of instruction. Those wishing to explore a more globalised curriculum were encouraged to undertake specialist postgraduate training at ...
John Goldsmid, Silvana Bettiol
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

The "100 Years of Tropical Medicine Conference" [PDF]

, 2010
The "100 Years of Tropical Medicine Conference" which is taking place from 11-14 June 2010 in Townsville, Australia, provides an ideal and timely opportunity to reflect on the contributions of our tropical medicine pioneers in Australia. This conference,
Leggat, Peter A., Porter, David C., Smith, Derek R.   +2 more
core   +1 more source

Carlos Chagas e os debates e controvérsias sobre a doença do Brasil (1909-1923) Carlos Chagas and the debates and controversies surrounding the disease of Brazil (1909-1923)

História, Ciências, Saúde: Manguinhos, 2009
Analisa o debate sobre a doença de Chagas, descoberta em 1909, em sua relação com a campanha pelo saneamento rural do Brasil (1916-1920). Argumenta que as bandeiras desse movimento estiveram diretamente referidas à definição e à legitimação dessa ...
Simone Petraglia Kropf
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Etiología parasitaria y obstáculos epistemológicos: el caso de la malaria en Colombia Parasite ethiology and epistemological obstacles: the case of malaria in Colombia

História, Ciências, Saúde: Manguinhos, 2007
Muestra el proceso que condujo a la medicina colombiana al descubrimiento y aceptación de las causas del paludismo, una enfermedad que aún azota en el país a grandes zonas cálidas y húmedas.
Victoria Estrada Orrego, Jorge Márquez Valderrama   +1 more
doaj   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Multi‐Scale Bionic Structure Constructs Biomass Flame‐Retardant Thermal Insulation Foam Material

Advanced Science, EarlyView.
Inspired by mussel adhesion and hierarchical brick‐and‐mortar architectures, a cellulose‐based biomimetic foam is constructed by anchoring bentonite nanosheets onto a polydopamine‐decorated cellulose nanofiber network. The resulting foam combines low thermal conductivity with intrinsic flame retardancy and full biodegradability, presenting a ...
Jianming Liao, Lijun Fan, Yunyuan Dong, Xuyu Bao, Xiaobin Chen, Qifu Zheng, Guanqing Zhang, Shen Wang, Wei Chen, Min Zhang, Shuaiming He   +10 more
wiley   +1 more source