Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1–associated myelopathy/tropical spastic paraparesis [PDF]
Proc Natl Acad Sci U S A, 2020 Significance HTLV-1 manifests many diseases, which cause morbidity and mortality in 5∼10% of infected individuals, including the fatal adult T cell leukemia/lymphoma (ATLL) and debilitating myelopathy (HAM/TSP).
M. Nagasaka +20 more
semanticscholar +2 more sources
Gut Microbiome Dysbiosis is Associated With Human T‐Lymphotropic Virus Type 1 (HTLV‐1) Infection and Disease Progression to HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis: A Cross‐Sectional Study [PDF]
Smart Medicine, Volume 5, Issue 1, February 2026.We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Lorena Abreu Fernandes +8 more
wiley +2 more sources
Paraparesia espástica tropical uma redefinição necessária Tropical spastic paraparesis: a necessary re-definition [PDF]
Arquivos de Neuro-Psiquiatria, 1996 O autor disserta sobre a definição de Paraparesia Espástica Tropical desde suas primeiras descrições até o envolvimento etiológico do HTLV-1 em parte dos casos.
Carlos Maurício de Castro-Costa
doaj +2 more sources
Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis [PDF]
J Neurovirol, 2020 Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Satoshi Nozuma, R. Kubota, S. Jacobson
semanticscholar +2 more sources
Immunopathogenesis and Cellular Interactions in Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis [PDF]
Front Microbiol, 2020 HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neuropathological disorder in 1–3% of individuals infected with Human T-lymphotropic virus 1 (HTLV-1). This condition is characterized by progressive spastic lower limb weakness and
Sepehr Aghajanian +3 more
semanticscholar +2 more sources
Cerebrospinal Fluid From Patients With HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) With Rapid Evolution Affects Mitochondrial DNA Transcription and Network Organization in Human Glioblastoma Cells [PDF]
Journal of Medical Virology, Volume 97, Issue 11, November 2025.ABSTRACT Human T‐lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurodegenerative disease affecting motor and sensory functions. While alterations in cerebrospinal fluid (CSF) have been used to identify disease biomarkers, the effects of such modified CSF on CNS cells remain unexplored.
Yago Côrtes Pinheiro Gomes +6 more
wiley +2 more sources
Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) [PDF]
Retrovirology, 2019 Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately 10–20 million people worldwide. While the majority of infected people are asymptomatic carriers of HTLV-1, only 4% of infected people develop HTLV-1-associated ...
Yoshimi Enose-Akahata, S. Jacobson
semanticscholar +2 more sources
Indian Journal of Neurosurgery, 2020 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an important cause of nontraumatic and noncompressive chronic myelopathy which generally has no improvement regardless of treatment.
Guilherme Gago +5 more
doaj +2 more sources
Tropical Spastic Paraparesis [PDF]
Definitions, 2019 TSP was initially described in tropical countries but has now also been identified in temperate countries (eg, southern Japan) as HTLV-1-associated myelopathy (HAM).
openaire +2 more sources
Cerebrospinal Fluid CXCL10 as a Candidate Surrogate Marker for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis [PDF]
Front Microbiol, 2019 Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a debilitating, progressive disease without effective treatment; therefore, development of disease modifying therapy that improves long-term ...
K. Tamaki +11 more
semanticscholar +2 more sources