Results 31 to 40 of about 3,589 (165)

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

Adult T‐cell leukemia/lymphoma in French Guiana (1990–2019): Epidemiology, clinical features, and HTLV‐1 genetic diversity in the two main ethnic populations

International Journal of Cancer, Volume 158, Issue 6, Page 1528-1540, 15 March 2026.
What's new? Adult T‐cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T‐cell leukemia virus type 1 (HTLV‐1). The authors comprehensively analyzed the epidemiological and clinical features of ATL over a 30‐year period in French Guiana, a region with high HTLV‐1 endemicity and a multiethnic population.
Jill‐Léa Ramassamy, Patricia Tortevoye, Balthazar Ntab, Gabriel Carles, Jean‐Pierre Droz, Pierre Couppié, Giovanni Begliomini, Jean‐Francois Carod, N'detodji‐Bill Wankpo, Karim Abdelmoumen, Philippe V. Afonso, Olivier Cassar, Antoine Talarmin, Olivier Hermine, Loïc Epelboin, Ambroise Marçais, Antoine Gessain   +16 more
wiley   +1 more source

Viral Pathogens and Pulmonary Fibrosis: EMT‐Driven Mechanisms and Insights From Traditional Chinese Medicine

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a serious progressive complication of the respiratory system, which is profoundly associated with persistent extracellular matrix (ECM) deposition, fibrosis, and disrupted tissue regeneration. Emerging evidence shows that epithelial–mesenchymal transition (EMT) acts as a key factor in the pathogenesis of ...
Ningzi Zang, Yingxu Wu, Pin Li, Yongming Liu, Shiwen Wang, Jiapeng Leng, Libin Zhan, Xiaodong Lyu, Lijian Pang, Jiaran Wang   +9 more
wiley   +1 more source

Approach to a case of myeloneuropathy

Annals of Indian Academy of Neurology, 2016
Myeloneuropathy is a frequently encountered condition and often poses a diagnostic challenge. A variety of nutritional, toxic, metabolic, infective, inflammatory, and paraneoplastic disorders can present with myeloneuropathy. Deficiencies of vitamin B12,
Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar   +2 more
doaj   +1 more source

HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Overlapping Ossification of the Ligamentum Flavum

Indian Journal of Neurosurgery, 2020
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an important cause of nontraumatic and noncompressive chronic myelopathy which generally has no improvement regardless of treatment.
Guilherme Gago, Luidia Varrone Giacomini, Frederico de Lima Gibbon, Euripedes Gomes de Carvalho Neto, Fernando Kowacs, Nelson Pires Ferreira   +5 more
doaj   +1 more source

Assessment of Awareness and Knowledge Regarding Human T‐Lymphotropic Virus Type 1 (HTLV‐1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023–2024, A Cross‐Sectional Descriptive‐Analytical Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aim Human T‐Lymphotropic Virus Type 1 (HTLV‐1), is responsible for serious diseases such as Adult T‐cell leukemia/lymphoma (ATLL) and HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This research aimed to explore the level of awareness and knowledge of HTLV‐1 among healthcare professionals working at Imam ...
Arash Letafati, Yasaman Goudarzi, Mohsen Sheikhi, Mahsa Afzali, Mehdi Norouzi, Kasra Allaei Rouzbahani, Marjan Ghasemi, Ahmadreza Sadeghi, Sayed‐Hamidreza Mozhgani   +8 more
wiley   +1 more source

Morbidity and Mortality Among People Living With HTLV‐1: A 30‐Year Retrospective Analysis in a Brazilian Cohort

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT HTLV‐1 infection is a chronic condition associated with the development of malignancies, inflammatory, and neurological disorders. In this study, the causes of hospitalization and mortality were assessed in a cohort of 508 individuals living with HTLV‐1 followed over a 30‐year period. Overall mortality was 8.5% in this population and increased
Elizabeth Souza Neves, Otavio Melo Espíndola, Raquel de Vasconcelos Carvalhaes de Oliveira, Ana Claudia Celestino Bezerra Leite, Marco Antonio Sales Dantas Lima, Marcus Tulius Teixeira Silva, Rafael Osellame, Pedro Abrahão Pinheiro Guimarães, Ricardo Vezzani Batista, André Luiz Anjos Oliveira, Abelardo Queiroz Campos Araújo   +10 more
wiley   +1 more source

HTLV-I associated myelopathy / tropical spastic paraparesis: report of the first cases in Rio Grande do Sul, Brazil Mielopatia associada ao HTLV-I/paraparesia espástica tropical: relato dos primeiros casos no Rio Grande do Sul, Brasil

Arquivos de Neuro-Psiquiatria, 1995
The HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), a myelopathy with predominant involvement of the pyramidal tract with minimal sensory loss and associated with HTLV-I infection, endemic in tropical areas, has been identified in ...
Sérgio Roberto Haussen, Maria Cecilia de Vecino   +1 more
doaj   +1 more source

PERFORMANCE OF THE GAIT IN INDIVIDUALS WITH HTLV-1: SYSTEMATIC REVIEW

Revista Pesquisa em Fisioterapia, 2017
HTLV-1 is frequently associated with myelopathy/tropical spastic paraparesis (HAM/TSP), which in turn brings several functional alterations to the individual, including changes in gait.
Mateus Evangelista do Amparo Santana, Livia Aguiar Pereira, Rafael Monteiro, Erika Pedreira Fonseca   +3 more
doaj   +1 more source

From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma

Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley   +1 more source