Results 51 to 60 of about 637,969 (209)

A comparative study of human T-cell lymphotropic virus-associated myelopathy in HIV-positive and HIV-negative patients in KwaZulu-Natal

Southern African Journal of HIV Medicine, 2017
Background: KwaZulu-Natal is an endemic area for HIV and human T-cell lymphotropic virus (HTLV) infection. The main neurological manifestation of HTLV is HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The effect of HIV co-infection in
Hoosain F. Paruk, Ahmed I. Bhigjee, Suzaan Marais   +2 more
doaj   +1 more source

HTLV-I associated myelopathy in salvador (northeastern Brazil)

Arquivos de Neuro-Psiquiatria, 1992
Recent studies of tropical spastic paraparesis have confirmed the existence of human T-cell leukemia virus type-1 (HTLVI) in several tropical areas of the world.
A. Meireles, E. D. Moreira Jr., O. A. Moreno-Carvalho, R. Badaro, A. Melo   +4 more
doaj   +1 more source

Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Meygol Mirzaei Rezaei, Mahdi Khosravi Nia, Kasra Allaei Rouzbahani, Maryam Kazemi, Negar Asghari Hosori, Mehdi Norouzi, Farzaneh Sotoudegan, Narges Eslami, Negar Ariamand, Vahid Shahnavaz, Arash Letafati, Sayed‑Hamidreza Mozhgani   +11 more
wiley   +1 more source

Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. [PDF]

PLoS ONE, 2014
HTLV-1 proviral loads (PVLs) and some genetic factors are reported to be associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, there are very few reports on HAM/TSP having family history.
Satoshi Nozuma, Eiji Matsuura, Toshio Matsuzaki, Osamu Watanabe, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima   +6 more
doaj   +1 more source

Low Prevalence of Human T‐Cell Lymphotropic Virus Type 1 (HTLV‐1) in a Hospital Triage Population in Tehran During 2024–2025

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Human T‐cell lymphotropic virus type 1 (HTLV‐1) is a retrovirus that is associated to adult T‐cell leukemia/lymphoma (ATLL) and HTLV‐1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) as two major diseases of the virus.
Arash Letafati, Shima Sadeghipour Marvi, Negar Asghari Hosori, Ghazale Molaverdi, Alireza Esfandiari, Nima Afshar Moghadam, Shabnam Siavoshi, Mehdi Norouzi, Sayed‐Hamidreza Mozhgani   +8 more
wiley   +1 more source

Pain and Quality of Life in Human T-cell Lymphotropic Virus Type 1-Associated Myelopathy or Tropical Spastic Paraparesis After Home-Based Exercise Protocol: A Randomized Clinical Trial.

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION Human T-cell lymphotropic virus type 1-associated myelopathy or tropical spastic paraparesis (HAM/TSP) causes, among other abnormalities, chronic pain that may impair quality of life (QOL).
M. Macêdo, Renata de Sousa Mota, Naiane Araújo Patrício, A. Baptista, A. S. A. Andrade Filho, K. Sá   +5 more
semanticscholar   +1 more source

Approach to a case of myeloneuropathy

Annals of Indian Academy of Neurology, 2016
Myeloneuropathy is a frequently encountered condition and often poses a diagnostic challenge. A variety of nutritional, toxic, metabolic, infective, inflammatory, and paraneoplastic disorders can present with myeloneuropathy. Deficiencies of vitamin B12,
Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar   +2 more
doaj   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

Adult T‐cell leukemia/lymphoma in French Guiana (1990–2019): Epidemiology, clinical features, and HTLV‐1 genetic diversity in the two main ethnic populations

International Journal of Cancer, Volume 158, Issue 6, Page 1528-1540, 15 March 2026.
What's new? Adult T‐cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T‐cell leukemia virus type 1 (HTLV‐1). The authors comprehensively analyzed the epidemiological and clinical features of ATL over a 30‐year period in French Guiana, a region with high HTLV‐1 endemicity and a multiethnic population.
Jill‐Léa Ramassamy, Patricia Tortevoye, Balthazar Ntab, Gabriel Carles, Jean‐Pierre Droz, Pierre Couppié, Giovanni Begliomini, Jean‐Francois Carod, N'detodji‐Bill Wankpo, Karim Abdelmoumen, Philippe V. Afonso, Olivier Cassar, Antoine Talarmin, Olivier Hermine, Loïc Epelboin, Ambroise Marçais, Antoine Gessain   +16 more
wiley   +1 more source

On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus I-—Associated myelopathy [PDF]

, 1999
The purpose of this review is to present some concepts on the etiology of tropical spastic paraparesis or human T-cell lymphotropic virus-I (HTLV-I)-associated myelopathy (TSP/HAM).
Zaninovic, Vladimir
core   +1 more source