Results 71 to 80 of about 6,507 (208)

Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers [PDF]

, 2011
Background Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a small percentage of infected individuals.
Ayako Takamori, Atsuhiko Hasegawa, Atae Utsunomiya, Yasuhiro Maeda, Yoshihisa Yamano, Masato Masuda, Yukiko Shimizu, Yotaro Tamai, Amane Sasada, Na Zeng, Ilseung Choi, Naokuni Uike, Jun Okamura, Toshiki Watanabe, Takao Masuda, Mari Kannagi   +15 more
core   +2 more sources

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1962-1970, October 2025.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima   +8 more
wiley   +1 more source

Alpha interferon restricts human T-lymphotropic virus type 1 and 2 De Novo infection through PKR activation [PDF]

, 2013
International audienceType I interferon (IFN-I) inhibits the replication of different viruses. However, the effect of IFN-I on the human T-lymphotropic virus type 1 (HTLV-1) viral cycle is controversial.
Alais, Sandrine, Cachat, Anne, Chevalier, Sebastien Alain, Dutartre, Helene, Journo, Chloe, Ko, Nga Ling, Mahleux, Renaud, Ratner, Lee   +7 more
core   +4 more sources

Inhibitors of Tax1‐PDZ Interactions Block HTLV‐1 Viral Transmission by Changing EV Composition

Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.
ABSTRACT Extracellular vesicles (EVs) are known to facilitate infection by enveloped RNA viruses including the Human T‐cell leukemia virus type‐1 (HTLV‐1). HTLV‐1‐encoded proteins, like the transactivator and oncoprotein Tax‐1, are loaded into EVs but their precise impact on EV cargos is not yet known.
Jedidja Puttemans, Yasmine Brammerloo, Karim Blibek, Jeremy Blavier, Thandokuhle Ntombela, Inge Van Molle, Julie Joseph, Julien Olivet, Deeya Saha, Manon Degey, Malik Hamaidia, Pooja Jain, Piel Geraldine, Pascale Zimmermann, Dae‐Kyum Kim, Dominique Baiwir, Makon‐Sébastien Njock, Franck Dequiedt, Kourosh Salehi‐Ashtiani, Steven Ballet, Alexander N. Volkov, Jean‐Claude Twizere, Sibusiso B. Maseko   +22 more
wiley   +1 more source

Sexual transmission of human T-cell lymphotropic virus type 1 [PDF]

, 2014
Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child.
Casseb, Jorge Simão do Rosário, Paiva, Arthur Maia   +1 more
core   +1 more source

HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract Viral infections are associated with the disruption of oxidative stress and the progression of inflammatory mechanisms that play pivotal roles in cardiovascular diseases. In the present study, several inflammatory and oxidative stress markers were examined in HTLV‐1‐infected male BALB/c mice.
Saeed Niazmand, S. A. Rahim Rezaee, Jamshid Gholizadeh Navashenaq, Nema Mohamadian Roshan, Mohsen Ghoryani, Houshang Rafatpanah, Maryam Mahmoudabady, Yousef Baghcheghi, Maryam Paseban, Mahdiyeh Hedayati‐Moghadam   +9 more
wiley   +1 more source

Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada [PDF]

, 2014
The 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses was held in Montreal, Québec from June 26 to June 30, 2013 and was therefore hosted by a Canadian city for the first time.
Barbeau, Benoit, Bazarbachi, Ali, Carvalho, Edgar, Hiscott, John, Jones, Kathryn, Martin, Fabiola, Matsuoka, Masao, Murphy, Edward L, Ratner, Lee, Switzer, William M, Watanabe, Toshiki   +10 more
core   +4 more sources

Enhancing Crop Nutrition in Arid and Semiarid Regions of Africa Through Genome Editing Using CRISPR/Cas

Food and Energy Security, Volume 14, Issue 3, May/June 2025.
ABSTRACT Food insecurity is a pressing issue in Africa, aggravated by escalating drought, jeopardizing the region's ability to meet nutritional requirements for human health. In arid and semiarid regions, crop yield is severely affected by drought and salinity.
Erick Amombo, Rita H. Mumm, Abdelaziz Nilahyane, Abdelaziz Hirich, Mohamed Hijri, Valentine Otang Ntui   +5 more
wiley   +1 more source

Rewired chromatin structure and epigenetic gene dysregulation during HTLV‐1 infection to leukemogenesis

Cancer Science, Volume 116, Issue 2, Page 513-523, February 2025.
We analyzed and evaluated cells infected with human T‐cell leukemia virus type 1 at different stages of infection in terms of gene expression and chromatin structure using ATAC sequencing and RNA sequencing. Our results revealed that infected cells exhibited significant changes in gene expression patterns from the polyclonal stage and before adult T ...
Jun Mizuike, Kako Suzuki, Shu Tosaka, Yuta Kuze, Seiichiro Kobayashi, Makoto Nakashima, Koji Jimbo, Yasuhito Nannya, Yutaka Suzuki, Kaoru Uchimaru, Makoto Yamagishi   +10 more
wiley   +1 more source

Human T‐Lymphotropic Virus Type 1–Associated Myelopathy With Autoimmune Cholangiopathy: An Unusual Immune Conundrum in a Young Patient

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Human​ T‐lymphotropic virus type 1 (HTLV‐1), the first oncogenic retrovirus discovered in humans, is primarily associated with two disease entities: adult T cell leukemia‐lymphoma and HTLV‐1‐associated myelopathy‐tropical spastic paresis. HTLV‐1 has also been implicated in the pathogenesis of various autoimmune rheumatic diseases, and its association ...
Aida Saad, Yamna Jadoon, Riffat Sabir, Piyush Baindara   +3 more
wiley   +1 more source