Results 71 to 80 of about 9,428 (208)

Danazol a new perspective in the treatment of htlv-l associated myelopathy (preliminary report)

open access: yesArquivos de Neuro-Psiquiatria, 1992
We investigated the efficacy of danazol treatment in eight patients with HTLV-l associated myelopathy/tropical spastic paraparesis (HAM/TSP). Treatment with danazol yielded clinical improvement of urinary control and gait disturbances in 7 out of the 8 ...
Ailton Melo   +3 more
doaj   +1 more source

HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice

open access: yesPhysiological Reports, Volume 13, Issue 11, June 2025.
Abstract Viral infections are associated with the disruption of oxidative stress and the progression of inflammatory mechanisms that play pivotal roles in cardiovascular diseases. In the present study, several inflammatory and oxidative stress markers were examined in HTLV‐1‐infected male BALB/c mice.
Saeed Niazmand   +9 more
wiley   +1 more source

Paraparesia espástica tropical uma redefinição necessária Tropical spastic paraparesis: a necessary re-definition

open access: yesArquivos de Neuro-Psiquiatria, 1996
O autor disserta sobre a definição de Paraparesia Espástica Tropical desde suas primeiras descrições até o envolvimento etiológico do HTLV-1 em parte dos casos.
Carlos Maurício de Castro-Costa
doaj   +1 more source

Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

open access: yesPLoS Neglected Tropical Diseases, 2017
HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).
M. Baratella   +7 more
semanticscholar   +1 more source

Enhancing Crop Nutrition in Arid and Semiarid Regions of Africa Through Genome Editing Using CRISPR/Cas

open access: yesFood and Energy Security, Volume 14, Issue 3, May/June 2025.
ABSTRACT Food insecurity is a pressing issue in Africa, aggravated by escalating drought, jeopardizing the region's ability to meet nutritional requirements for human health. In arid and semiarid regions, crop yield is severely affected by drought and salinity.
Erick Amombo   +5 more
wiley   +1 more source

Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010)

open access: yesPLoS Neglected Tropical Diseases, 2018
Background Human T-lymphotropic virus type 1 (HTLV-1) has been discovered in 1980 and has been linked to tropical spastic paraparesis (HAM/TSP) in 1985 in Martinique. There is no data on HAM/TSP incidence trends.
S. Olindo   +12 more
semanticscholar   +1 more source

Rewired chromatin structure and epigenetic gene dysregulation during HTLV‐1 infection to leukemogenesis

open access: yesCancer Science, Volume 116, Issue 2, Page 513-523, February 2025.
We analyzed and evaluated cells infected with human T‐cell leukemia virus type 1 at different stages of infection in terms of gene expression and chromatin structure using ATAC sequencing and RNA sequencing. Our results revealed that infected cells exhibited significant changes in gene expression patterns from the polyclonal stage and before adult T ...
Jun Mizuike   +10 more
wiley   +1 more source

Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study.

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 2018
INTRODUCTION Human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) may lead to reduced functional mobility and balance. It is important to establish specific parameters that identify these changes and predict
E. Fonseca   +5 more
semanticscholar   +1 more source

Human T‐Lymphotropic Virus Type 1–Associated Myelopathy With Autoimmune Cholangiopathy: An Unusual Immune Conundrum in a Young Patient

open access: yesCase Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Human​ T‐lymphotropic virus type 1 (HTLV‐1), the first oncogenic retrovirus discovered in humans, is primarily associated with two disease entities: adult T cell leukemia‐lymphoma and HTLV‐1‐associated myelopathy‐tropical spastic paresis. HTLV‐1 has also been implicated in the pathogenesis of various autoimmune rheumatic diseases, and its association ...
Aida Saad   +3 more
wiley   +1 more source

Stability and Perpetuation of Human T‐Lymphotropic Virus 1 (HTLV‐1) in Intrafamilial Transmissions of Infection in an Endemic Region of the Brazilian Amazon: A Pilot Study

open access: yesJournal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Introduction Human T‐lymphotropic virus 1 (HTLV‐1) is related to several clinical diseases, including adult T‐cell leukemia/lymphoma and HTLV‐1‐associated myelopathy. Intrafamilial transmission of HTLV‐1 is rarely reported in Brazil and worldwide. Objective To identify HTLV‐1 family transmissions in Belem, Para, the Amazon region of Brazil.
Cássia Cristine Costa Pereira   +9 more
wiley   +1 more source

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