Results 221 to 230 of about 95,222 (302)

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Cardiac AAV gene therapy: Translational lessons from intracoronary cardiomyocyte-targeted delivery. [PDF]

Mol Ther Nucleic Acids
Henry TD, Roessig L, Sanganalmath S, Roberts L, Jiang C, Kranias EG, Hajjar RJ.   +6 more
europepmc   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Comparative Transduction Profiling of Four Intravenously Delivered AAV Capsids in the Neonatal Murine Nervous System. [PDF]

Biomedicines
Gao H, Xu T.
europepmc   +1 more source

Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small‐Cell Lung Cancer Models

Cancer Science, EarlyView.
Dietary NA restriction converts the effect of NAMPT inhibition from cytostatic to cytotoxic in SCLC in vivo. ABSTRACT Small‐cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models ...
Kyoji Tsurumi, Miyuki Nomura, Mai Ouchi, Shigehiro Yagishita, Naohiko Kikuchi, Taku Sato, Mami Morita, Yoji Yamashita, Kayoko Hayashi, Tomoyoshi Soga, Akinobu Hamada, Tatsuro Fukuhara, Nobuhiro Tanuma   +12 more
wiley   +1 more source

Next-generation experimental techniques for mRNA lipid nanoparticle evaluation and protein interaction analysis. [PDF]

Mol Ther Nucleic Acids
Hamilton AG, Mitchell MJ.
europepmc   +1 more source

Integrated Transcriptomics of Human and Canine Osteosarcoma Reveals Species Stemness and Trabectedin Sensitivity

Cancer Science, EarlyView.
Comprehensive comparative molecular framework for human and canine osteosarcomas. Integrated transcriptomic analyses establish a comprehensive comparative molecular framework for human and canine osteosarcomas. By defining species‐specific stemness architectures and drug response dynamics, our findings highlight the necessity of accounting for distinct
Kenta Kono, Yomogi Shiota, Ting‐Ting Shu, Hayato Shibahara, Daiki Kato, Takayuki Nakagawa, Seiji Ohtori, Tadashi Kondo   +7 more
wiley   +1 more source

Powassan Virus Infects Mouse Testes and Reveals a Protective Role for Phagocytic Cells. [PDF]

Viruses
Hager-Soto EE, Arroyave E, Eyzaguirre E, Saldarriaga OA, Freiberg AN, Rossi SL.   +5 more
europepmc   +1 more source