Results 101 to 110 of about 4,779 (198)

Hypoxia downregulates tropoelastin gene expression in rat lung fibroblasts by pretranslational mechanisms

, 1999
Elastolytic lung injury disrupts cell barriers, flooding alveoli and producing regional hypoxia. Abnormal O2tensions may alter repair of damaged elastin fibers.
Ronald H. Goldstein, John L. Berk, Christine Hatch, Nima Massoomi   +3 more
core   +1 more source

Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA

International Journal of COPD, 2017
Lian Wu,1,2 Jing Zhang,3 Jie Ming Qu,4 Chun-xue Bai,3 Mervyn J Merrilees5 1Department of Community and Health Services, Unitec, 2Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand; 3Department of ...
Wu L, Zhang J, Qu JM, Bai CX, Merrilees MJ   +4 more
doaj  

A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function

, 2012
Reendothelialization of the stent surface after percutaneous coronary intervention (PCI) is known to be an important determinant of clinical outcome. We compared the effects of biological stent coatings, fibronectin, fibrinogen and tropoelastin, on human
Roest, Mark, Tersteeg, Claudia, Mak-Nienhuis, Elske M., Ligtenberg, Erik, de Groot, Philip G., Pasterkamp, Gerard, Hoefer, Imo E.   +6 more
core   +1 more source

Protein malnutrition impairs skin elasticity in hairless mice by downregulating tropoelastin, fibrillin-1, and lysyl oxidase-like protein-1

Beni-Suef University Journal of Basic and Applied Sciences
Background Malnutrition is a known cause of skin disorders, but the genetic mechanisms linking it to dermal dysfunctions, particularly skin elasticity, are not fully understood.
Toshihiro KOBAYASHI, Akihiko SUGIYAMA, Yasushi SUZUKI, Takashi TAKEUCHI   +3 more
doaj   +1 more source

Biphasic response of tropoelastin at the poststenotic dilation segment of the rabbit aorta

, 2002
Objective: The purpose of this study was to assess the time course of tropoelastin gene expression in the poststenotic dilatation segment of rabbit aorta with experimental coarctation.
Glagov, Seymour, Zarins, Christopher K., Xu, Chengpei   +2 more
core   +1 more source

Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin

, 2005
In forming elastic fibers, microfibrils act as the scaffold sites for depositing the elastin precursor tropoelastin. We examined key binding interactions that promote massive tropoelastin association through coacervation.
Kielty, Cay M., Wise, Steven G., Cain, Stuart A.; id_orcid, Clarke, Adam W., Weiss, Anthony S.   +4 more
core   +1 more source

Tropoelastin and Elastin Assembly

Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience and cell interactivity to a broad range of elastic tissues. Elastin makes up the majority of elastic fibers and is formed by the hierarchical assembly of
Weiss, Anthony S, Cain, Stuart; id_orcid, Tarakanova, Anna, Baldock, Clair, Ozsvar, Jazmin, Yang, Chengeng   +5 more
core   +1 more source

Dimethylacrylamide-based gels for expansion microscopy across different solvents

Materials Today Advances
Expansion microscopy (ExM) enables super-resolution visualization using standard light microscopes. Recent developments have explored dimethylacrylamide (DMAA) to improve gel robustness, but compatibility with organic solvents remains a challenge.
Murilo Izidoro Santos, Zviadi Katcharava, Prerak Dhawan, Tobias Hedkte, Wolfgang H. Binder, Christian E.H. Schmelzer, Sébastien Blaise, Ralf B. Wehrspohn, Juliana Martins de Souza e Silva   +8 more
doaj   +1 more source

Effect of monoclonal antibodies to defined regions of tropoelastin on elastogenesis in vitro.

, 1992
Primary cultures of chick embryo aorta cells were grown for one week in the presence of mouse monoclonal antibodies directed against defined regions of chick tropoelastin.
MARIGO, Valeria, BRESSAN G. M., VOLPIN D., DAGA GORDINI D., SITTA A.   +4 more
core   +1 more source

Assessing the feasibility of CRISPRa approaches to enhance protein-based biomaterial expression in bacterial systems for more efficient production

Materials Today Bio
Recombinant protein production is crucial for biomedical and industrial applications; however, achieving high yields for complex protein-like biomaterials such as elastin-like recombinamers (ELRs) remains challenging. ELRs, protein-based polymers derived
Pablo Rodríguez-Alonso, Viktoriya Chaskovska, Desiré Venegas-Bustos, Alba Herraiz, Matilde Alonso, Jose Carlos Rodríguez-Cabello   +5 more
doaj   +1 more source