Results 211 to 220 of about 7,724 (232)
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Degradation of tropoelastin by proteases
Analytical Biochemistry, 1978Abstract A simple assay is described which is capable of detecting single breaks in purified radioactively labeled tropoelastin after incubation with dilute solutions of proteases. Using this assay we show that tropoelastin is rapidly cleaved by a variety of proteases, including leukocyte and pancreatic clastase, at physiologic pH and ionic strength.
P, Christner +3 more
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Characterization of rat heart tropoelastin
Archives of Biochemistry and Biophysics, 1989Several overlapping rat tropoelastin cDNA clones were isolated from a lambda gt11 rat heart cDNA library and their nucleotide sequence was determined. The corresponding deduced amino acid sequence of rat tropoelastin revealed strong homology to bovine and human tropoelastins although possessing some unique features including greater size (18%) and ...
C B, Rich, J A, Foster
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Tropoelastin Expression by Periodontal Fibroblasts
Journal of Dental Research, 2002Elastic system fibers are load-bearing proteins found in periodontal tissue. There are three types—oxytalan, elaunin, and elastic fibers—which differ in their relative microfibril and elastin contents. Oxytalan fibers are known to be distributed in the periodontal ligaments and gingiva, whereas elaunin and elastic fibers are present only in the ...
E, Tsuruga +3 more
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Primary Structure of Porcine Tropoelastin
1977Structural studies on porcine aortic tropoelastin as obtained from copper-deficient swine have been performed on the whole protein as well as fragments produced by trypsin, subtilisin and thrombin digestion. Tryptic fragments fall into two catagories, those large, over 20 residues, and those small, 4 residues and less.
L B, Sandberg +5 more
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Biosynthesis of Tropoelastin by Elastic Cartilage
Connective Tissue Research, 1980Elastic ear cartilage and aortae from nine-day-old hamsters were incubated in Krebs-Ringer medium containing ascorbate, beta-aminopropionitrile and either [14C]proline or [3H]valine. The [14C]proline-labeled proteins were separated by chromatography on Agarose A-5 m in sodium dodecyl sulfate and their [14C]-hydroxyproline content measured.
P, Heeger, J, Rosenbloom
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MMP-14 degrades tropoelastin and elastin
Biochimie, 2019Matrix metalloproteinases are a class of enzymes, which degrade extracellular matrix components such as collagens, elastin, laminin or fibronectin. So far, four matrix metalloproteinases have been shown to degrade elastin and its precursor tropoelastin, namely matrix metalloproteinase-2, -7, -9 and -12.
Natalia Miekus +5 more
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Biocompatibility of silk-tropoelastin protein polymers
Biomaterials, 2014Blended polymers are used extensively in many critical medical conditions as components of permanently implanted devices. Hybrid protein polymers containing recombinant human tropoelastin and silk fibroin have favorable characteristics as implantable scaffolds in terms of mechanical and biological properties. A firefly luciferase transgenic mouse model
Hongjuan, Liu +7 more
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Tropoelastin — A multifaceted naturally smart material
Advanced Drug Delivery Reviews, 2013Tropoelastin dominates the physical performance of human elastic tissue as it is assembled to make elastin. Tropoelastin is increasingly appreciated as a protein monomer with a defined solution shape comprising modular, bridged regions that specialize in elasticity and cell attachment, which collectively participate in macromolecular assembly.
Suzanne M, Mithieux +2 more
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Intrinsic enzyme activity associated with tropoelastin
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976The presence of an enzyme(s) associated with purified tropoelastin has been established. Results indicate that the enzyme(s) remains closely associated with the soluble elastin throughout the entire purification procedure suggesting that it is very tightly bound. Enzymatic activity is optimum through the pH range 7-9 (37 degrees C) and can be inhibited
R P, Mecham, J A, Foster, C, Franzblau
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Fibrillation of tropoelastin induced by proteoglycan
Experientia, 1976Electrostatic interaction between tropoelastin, the native precursor of elastin, and proteoglycan results in tropoelastin fibrillation. The finding suggests a possible involvement of proteoglycans in elastogenesis.
M, Adam, V, Podrazký
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