Results 221 to 230 of about 6,608 (237)
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Flexibility in the Solution Structure of Human Tropoelastin
Biochemistry, 2007We investigated the flexibility of full-length tropoelastin in solution by using far- and near-ultraviolet circular dichroism (UV CD) and fluorescence spectroscopy to probe for structural flexibility and residue mobility within secondary and tertiary features of the monomer.
Lisa D. Muiznieks, Anthony S. Weiss
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Synthesis of a cross‐linked polypentapeptide of tropoelastin
Biopolymers, 1976AbstractThe synthesis of a cross‐linked polypentapeptide (an insoluble product) by means of a cross‐linking reaction between a lysine‐containing (1%) polypentapeptide and a glutamic acid‐containing (2%) polypentapeptide is described, following description of the synthesis and polymerization of the corresponding pentapeptide p‐nitrophenyl esters.
D. W. Urry, K. Okamoto
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Degradation of tropoelastin and skin elastin by neprilysin
Biochimie, 2018Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation. However, information on its elastase activity is still limited. The aim of this study was to investigate the degradation of fibrillar skin elastin by
Chiara Luise +7 more
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Structural changes and facilitated association of tropoelastin
Archives of Biochemistry and Biophysics, 2003Circular dichroism studies of tropoelastin secondary structure show 4+/-1% alpha-helix in aqueous solutions. This is in contrast to the substantially higher amounts (up to 23+/-7%) of alpha-helix predicted by computer algorithms, which propose that regions of alpha-helix are limited to the alanine-rich cross-linking domains.
Sacha A. Jensen +2 more
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Matrix Biology, 2005
A number of reports point to the presence of proteoglycans and/or glycosaminoglycans within elastic fibers in normal and in pathological conditions. We present data that heparan sulphate (HS)-containing proteoglycans are associated with normal elastic fibers in human dermis and that isolated HS chains interact in vitro with recombinant tropoelastin and
GHEDUZZI, Dealba +8 more
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A number of reports point to the presence of proteoglycans and/or glycosaminoglycans within elastic fibers in normal and in pathological conditions. We present data that heparan sulphate (HS)-containing proteoglycans are associated with normal elastic fibers in human dermis and that isolated HS chains interact in vitro with recombinant tropoelastin and
GHEDUZZI, Dealba +8 more
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Evidence that Tropoelastin Exists as a Random Coil
1977Cells isolated from the aortae of 17-day old embryonic chicks were incubated with [3H]valine in Krebs-Ringer medium and the secreted labeled tropoelastin was isolated. This tropoelastin was studied by zone velocity centrifugation in sucrose density gradient over the pH range 2.5–12.0, and temperatures ranging from 4° to 35°.
Joel Rosenbloom +2 more
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Improved methodologies for the isolation and purification of tropoelastin
Analytical Biochemistry, 1980Abstract Increased yields of purified tropoelastin were obtained from lathyritic chicks which had been raised on normal commercial starting feed for 1 week followed by 8 days on commercial starting feed supplemented with 0.1% aminoacetonitrile·HCl and 0.05% ϵ-aminocaproic acid.
Celeste B. Rich +4 more
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Biocompatibility of silk-tropoelastin protein polymers
Biomaterials, 2014Blended polymers are used extensively in many critical medical conditions as components of permanently implanted devices. Hybrid protein polymers containing recombinant human tropoelastin and silk fibroin have favorable characteristics as implantable scaffolds in terms of mechanical and biological properties. A firefly luciferase transgenic mouse model
Marcela M.M. Bilek +7 more
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MMP-14 degrades tropoelastin and elastin
Biochimie, 2019Matrix metalloproteinases are a class of enzymes, which degrade extracellular matrix components such as collagens, elastin, laminin or fibronectin. So far, four matrix metalloproteinases have been shown to degrade elastin and its precursor tropoelastin, namely matrix metalloproteinase-2, -7, -9 and -12.
Chiara Luise +9 more
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The International Journal of Biochemistry & Cell Biology, 2004
Fibulin-5 (also known as DANCE) is an elastin-binding protein that is thought to play a role in elastogenesis. We examined the relationship between the gene expression of fibulin-5 and the gene expression and accumulation of tropoelastin by comparing elastin-producing cells (human gingival fibroblasts) with non-elastin-producing cells (human ...
Eichi Tsuruga +2 more
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Fibulin-5 (also known as DANCE) is an elastin-binding protein that is thought to play a role in elastogenesis. We examined the relationship between the gene expression of fibulin-5 and the gene expression and accumulation of tropoelastin by comparing elastin-producing cells (human gingival fibroblasts) with non-elastin-producing cells (human ...
Eichi Tsuruga +2 more
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