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The International Journal of Biochemistry & Cell Biology, 2009
Tropoelastin is a 60-72 kDa alternatively spliced extracellular matrix protein and a key component of elastic fibres. It is found in all vertebrates except for cyclostomes. Secreted tropoelastin is tethered to the cell surface, where it aggregates into organised spheres for cross-linking and incorporation into growing elastic fibres.
Steven G, Wise, Anthony S, Weiss
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Tropoelastin is a 60-72 kDa alternatively spliced extracellular matrix protein and a key component of elastic fibres. It is found in all vertebrates except for cyclostomes. Secreted tropoelastin is tethered to the cell surface, where it aggregates into organised spheres for cross-linking and incorporation into growing elastic fibres.
Steven G, Wise, Anthony S, Weiss
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Advances in Colloid and Interface Science, 2011
The coacervation of tropoelastin represents the first major stage of elastic fiber assembly. The process has been modeled in vitro by numerous studies, initially with mixtures of solubilized elastin, and subsequently with synthetic elastin peptides that represent hydrophobic repeat units, isolated hydrophobic domains, segments of alternating ...
Giselle C, Yeo +2 more
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The coacervation of tropoelastin represents the first major stage of elastic fiber assembly. The process has been modeled in vitro by numerous studies, initially with mixtures of solubilized elastin, and subsequently with synthetic elastin peptides that represent hydrophobic repeat units, isolated hydrophobic domains, segments of alternating ...
Giselle C, Yeo +2 more
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Tubular fibrous scaffold functionalized with tropoelastin as a small-diameter vascular graft.
Biomacromolecules, 2020Cardiovascular disorders are a healthcare problem in today´s society. The clinically available synthetic vascular grafts are thrombogenic and could induce intimal hyperplasia.
S. Oliveira +8 more
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Properties of chick tropoelastin
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1973Abstract 1. 1. Tropoelastin was purified from the aortas of copper-deficient chicks. The amino acid composition of this protein is very similar to that previously described for porcine tropoelastin. The protein contains more than 40 residues of lysine per thousand total residues and no desmosine or isodesmosine. 2. 2.
R B, Rucker +2 more
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Intracellular trafficking of tropoelastin
Matrix Biology, 1998Elastin is secreted as soluble tropoelastin monomers which are then cross-linked in the presence of extracellular microfibrils to form insoluble elastic fibers. Although the secretion of tropoelastin is thought to be mediated and targeted by an intracellular chaperone complex, the intracellular route taken by this protein and the role of such a ...
E C, Davis, R P, Mecham
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1977
The presence of an enzyme associated with tropoelastin is described. The enzyme has a pH optimum between 7 and 9 and trypsin-like specificity. Upon incubation, tropoelastin (72,000 molecular weight) is cleaved into relatively high molecular weight fragments. In addition to the parent molecule, five discrete polypeptide bands are usually observed on SDS
R, Mecham, J A, Foster, C, Franzblau
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The presence of an enzyme associated with tropoelastin is described. The enzyme has a pH optimum between 7 and 9 and trypsin-like specificity. Upon incubation, tropoelastin (72,000 molecular weight) is cleaved into relatively high molecular weight fragments. In addition to the parent molecule, five discrete polypeptide bands are usually observed on SDS
R, Mecham, J A, Foster, C, Franzblau
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Degradation of tropoelastin by proteases
Analytical Biochemistry, 1978Abstract A simple assay is described which is capable of detecting single breaks in purified radioactively labeled tropoelastin after incubation with dilute solutions of proteases. Using this assay we show that tropoelastin is rapidly cleaved by a variety of proteases, including leukocyte and pancreatic clastase, at physiologic pH and ionic strength.
P, Christner +3 more
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Characterization of rat heart tropoelastin
Archives of Biochemistry and Biophysics, 1989Several overlapping rat tropoelastin cDNA clones were isolated from a lambda gt11 rat heart cDNA library and their nucleotide sequence was determined. The corresponding deduced amino acid sequence of rat tropoelastin revealed strong homology to bovine and human tropoelastins although possessing some unique features including greater size (18%) and ...
C B, Rich, J A, Foster
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Science Translational Medicine
Treatment of injuries to soft elastic organs is often hindered by challenging anatomical features and limitations of existing sealant materials, which may lack adequate tissue adhesion, elasticity, biocompatibility, and effective hemostatic properties ...
Mahsa Ghovvati +10 more
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Treatment of injuries to soft elastic organs is often hindered by challenging anatomical features and limitations of existing sealant materials, which may lack adequate tissue adhesion, elasticity, biocompatibility, and effective hemostatic properties ...
Mahsa Ghovvati +10 more
semanticscholar +1 more source
Novel Recombinant Tropoelastin Implants Restore Skin Extracellular Matrix.
Journal of Drugs in Dermatology, 2020BACKGROUND Elastin is an essential component of the dermis, providing skin with elasticity and integrity. Elastin and other dermal components are gradually lost through aging, sun damage, and following injury, highlighting a need to replace these ...
Michal Graff Mitzmacher +4 more
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