Results 161 to 170 of about 302,760 (242)

KinDEL: DNA-Encoded Library Dataset for Kinase Inhibitors [PDF]

arXiv
DNA-Encoded Libraries (DEL) are combinatorial small molecule libraries that offer an efficient way to characterize diverse chemical spaces. Selection experiments using DELs are pivotal to drug discovery efforts, enabling high-throughput screens for hit finding.
arxiv  

Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation

Brain Research Bulletin
Background: Transcranial direct current stimulation (tDCS) has an impact on improving cognitive and motor dysfunction induced by ischemia-reperfusion injury.
Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong   +4 more
doaj  

Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development.

PLoS Genetics
BackgroundThe development and diversification of sensory proprioceptive neurons, which reside in the dorsal root ganglia (DRG) and express the tropomyosin receptor kinase C (TrkC), depend on the transcription factor (TF) Runx3.
Kira Orlovsky, Elena Appel, Shay Hantisteanu, Tsviya Olender, Joseph Lotem, Ditsa Levanon, Yoram Groner   +6 more
doaj   +1 more source

The Cyclin-Dependent Kinase Inhibitor and Tumor Suppressor Locus p16/INK4A- p14ARF and Regulation of the Transition Into and Out of the Cell Cycle [PDF]

, 2011
p16/INK4A/CDKN2A is an important tumor suppressor gene located in the INK4A/ARF locus, which encodes a 16 kDa protein known as p16, and a 14 kDa protein known as p14ARF in humans. p16 arrests cell cycle in early G1 phase thereby inhibiting the binding of
Agarwal, Payal
core  

Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells

Redox Biology, 2017
N-acetyl serotonin (NAS) as a melatonin precursor has neuroprotective actions. Nonetheless, it is not clarified how NAS protects neuronal cells against oxidative stress.
Jae-Myung Yoo, Bo Dam Lee, Dai-Eun Sok, Jin Yuel Ma, Mee Ree Kim   +4 more
doaj  

Role of TRKC and NT-3 proteins in the progression and prognosis of colorectal cancer. [PDF]

Transl Cancer Res
Chen S, Rao Y, Liu W, Yang Q, Wu G, Wu F, Gao Y, Li J, Fu J.   +8 more
europepmc   +1 more source

Larotrectinib Compared With Real-World Non-Tropomyosin Receptor Kinase Inhibitor Therapies in Patients With Tropomyosin Receptor Kinase Fusion Cancer. [PDF]

JCO Precis Oncol
Brose MS, Westphalen CB, Pan X, Bernard-Gauthier V, Kurtinecz M, Guo H, Aris V, Brett NR, Majdi A, Subbiah V, Pennell NA, Kehl KL, Drilon A.   +12 more
europepmc   +1 more source

Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression. [PDF]

World J Gastroenterol
Wang JJ, Fan YH, Cao WT, Huang R, Yao XY, Li ML.   +5 more
europepmc   +1 more source

NGF in Neuropathic Pain: Understanding Its Role and Therapeutic Opportunities. [PDF]

Curr Issues Mol Biol
García-Domínguez M.
europepmc   +1 more source

Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis. [PDF]

Medicina (Kaunas)
Choi J, Kim J, Jung YW, Park JH, Lee JH.
europepmc   +1 more source