Results 181 to 190 of about 31,127 (214)

TPM3-NTRK1 Fusion Cervical Sarcoma: A Case Report of a Novel Subset of Gynaecological Sarcomas and Successful Treatment of Recurrent Disease With Trk-Inhibition Therapy. [PDF]

Cureus
Lowe-Zinola J, Elghobashy M, Evans M, Hafeez T, El-Ghobashy A.   +4 more
europepmc   +1 more source

Cerebral Dopamine Neurotrophic Factor (CDNF) Acts as a Trophic Factor Promoting Neuritogenesis in the Dorsal Root Ganglia (DRG) Neurons Through Activation of the PI3K Signaling Pathway. [PDF]

J Neurochem
de Siqueira Santos R, Borba FN, de Oliveira DF, Santiago MF, do Nascimento AM, Schechtman D, Foguel D.   +6 more
europepmc   +1 more source

Larotrectinib Compared With Real-World Non-Tropomyosin Receptor Kinase Inhibitor Therapies in Patients With Tropomyosin Receptor Kinase Fusion Cancer. [PDF]

JCO Precis Oncol
Brose MS, Westphalen CB, Pan X, Bernard-Gauthier V, Kurtinecz M, Guo H, Aris V, Brett NR, Majdi A, Subbiah V, Pennell NA, Kehl KL, Drilon A.   +12 more
europepmc   +1 more source

Role of hsa-miR-122-5p in chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease: Targeting PIK3CG in the PI3K/Akt signaling pathway. [PDF]

Medicine (Baltimore)
Chen R, Ye W, Yang Y, Liao H, Sun T, Liao W, Li H, Li K, Chen M, Cheng J, Zheng Z, Yao W.   +11 more
europepmc   +1 more source

Novel Insights Into Receptor Tyrosine Kinases in Pulmonary Arterial Hypertension. [PDF]

J Am Heart Assoc
Wu W, Kong F, Chen Z, Huang L, Nie X, Bian JS.   +5 more
europepmc   +1 more source

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Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor

European Journal of Medicinal Chemistry, 2022
Tropomyosin receptor kinases (TRKs) are a family of TRKA, TRKB and TRKC isoforms. It has been widely reported that TRKs are implicated in a variety of tumors with several Pan-TRK inhibitors currently being used or evaluated in clinical treatment. However, off-target adverse events frequently occur in the clinical use of Pan-TRK inhibitors, which result
Zhijie Wang, Jiwei Ren, Kun Jia, Yuming Zhao, Li Liang, Zitian Cheng, Fei Huang, Xiaofei Zhao, Jie Cheng, Shiyu Song, Tiancheng Sheng, Weiqi Wan, Qingqing Shu, Donglin Wu, Junhao Zhang, Tao Lu, Yadong Chen, Ting Ran, Shuai Lu   +18 more
openaire   +2 more sources

Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity

Food and Chemical Toxicology, 2020
Manganese (Mn), an essential micronutrient, has the potential to induce apoptosis. The NT3/TrkC ligand/receptor pair known as part of the classic neurotrophic theory plays a critical role in neuronal survival. However, whether the NT3/TrkC-mediated signaling pathways are involved in Mn-induced apoptosis of cortical neurons remains unknown.
Yiping, Yang, Fu, Wei, Jian, Wang, Rui, Chen, Jie, Zhang, Danni, Li, Dong, Gan, Xiaobo, Yang, Yunfeng, Zou   +8 more
openaire   +2 more sources

Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma

Human Pathology, 2013
Members of the tropomyosin receptor kinase (Trk) family have a high affinity for neurotrophins and regulate neuronal survival. The role of Trks in cancer is still controversial. The expression and role of TrkB and TrkC were examined in colorectal cancer (CRC). Immunohistochemical analysis of TrkB and TrkC was performed in 133 patients with CRC.
Tomonori, Sasahira, Nobuhiro, Ueda, Miyako, Kurihara, Sayako, Matsushima, Hitoshi, Ohmori, Kiyomu, Fujii, Ujjal K, Bhawal, Kazuhiko, Yamamoto, Tadaaki, Kirita, Hiroki, Kuniyasu   +9 more
openaire   +2 more sources

Expression of neurotrophin 3 and its tropomyosin-related kinase receptor C in human preantral follicles

Fertility and Sterility, 2011
To investigate the expression of neurotrophin 3 (NT3) and its receptor tropomyosin-related kinase C (TrkC) in human preantral follicles. Neurotrophins appear to play important roles in preantral follicles. Data on ovarian NT3 and its receptor TrkC are sparse in humans.Immunohistochemical, in situ hybridization, and reverse transcriptase polymerase ...
Galia, Oron, Asangla, Ao, Or, Friedman, Benjamin, Fisch, Xiao Yun, Zhang, Avi, Ben-Haroush, Yoav, Peled, Ronit, Abir   +7 more
openaire   +2 more sources

Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

Journal of Medicinal Chemistry, 2016
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical activity of crizotinib (Xalkori), the first ALK inhibitor approved in 2011, the emergence of resistance mutations and of brain metastases frequently causes relapse in patients.
Maria, Menichincheri, Elena, Ardini, Paola, Magnaghi, Nilla, Avanzi, Patrizia, Banfi, Roberto, Bossi, Laura, Buffa, Giulia, Canevari, Lucio, Ceriani, Maristella, Colombo, Luca, Corti, Daniele, Donati, Marina, Fasolini, Eduard, Felder, Claudio, Fiorelli, Francesco, Fiorentini, Arturo, Galvani, Antonella, Isacchi, Andrea Lombardi, Borgia, Chiara, Marchionni, Marcella, Nesi, Christian, Orrenius, Achille, Panzeri, Enrico, Pesenti, Luisa, Rusconi, Maria Beatrice, Saccardo, Ermes, Vanotti, Ettore, Perrone, Paolo, Orsini   +28 more
openaire   +2 more sources