Results 91 to 100 of about 14,082,843 (400)

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source

Association Between Postoperative Troponin Levels and 90 Days Mortality Among Patients Undergoing Non-Cardiac Surgery

Pakistan Journal of Medicine and Dentistry
Background: Globally, the mortality of non-cardiac surgery patients within the first month is increasing. Monitoring troponin-I levels aids in early mortality risk identification.
Madiha Haroon, Areeba Abdullah, Faisal Siddiqi, Mirza Arshad Beg, Anum Arshad Beg   +4 more
doaj   +1 more source

Can troponin-I be used as an independent predictor of cardiac dysfunction after supraventricular tachycardia in children with structural normal heart? [PDF]

Vojnosanitetski Pregled, 2019
Introduction. Elevated cardiac troponin gives excellent accuracy in the identification of myocardial damage in children, but it can also be elevated in a series of other diseases. Case report.
Simović Aleksandra M., Tanasković-Nestorović Jelena M., Knežević Sanja M., Vuletić Biljana P., Stojković Anđelka K., Jeremić Dejan M., Jovanović Milan, Vulović Maja   +7 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Assessment of cardiac troponin I in patients with pulmonary emboli and its relationship with right ventricular dysfunction

Journal of Mazandaran University of Medical Sciences, 2009
(Received 16 December, 2008; Accepted 27 May, 2009)AbstractBackground and purpose: Right ventricular dysfunction is common in major pulmonary embolisms. The purpose of this study was to evaluate the prevalence and diagnostic utility of cardiac troponin I
Sasan Tavana, Yunes Panahi, Nasrollah Saed Moucheshi, Fatemeh Beiraghdar, Ebrahim Naderi3Department of Internal Medicine, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran, Shahram Ala, Rouhollah Habibey   +6 more
doaj  

Cardiac troponin I (CTnI) level among children with epileptic seizures

The Egyptian Heart Journal, 2014
Epilepsy is a common chronic neurological disorder in pediatric age characterized by recurrent, unprovoked seizures; these seizures are transient signs of abnormal excessive or hyper synchronous neuronal activity in the brain.
Ahmed Anwer Attia Khattab, Sameh Abdallah Abd-Elnaby, Ashrf Abd-Elraaof Dwood, Maha Attia Hagras   +3 more
doaj   +1 more source

Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction. [PDF]

PLoS ONE, 2013
Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus.
Hatice Betül Erer, Tolga Sinan Güvenç, Ahu Sarbay Kemik, Hale Yaka Yılmaz, Şeref Kul, Servet Altay, Nurten Sayar, Yüksel Kaya, Mehmet Eren   +8 more
doaj   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source