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Standardization of troponin I measurements: an update [PDF]

Clinical Chemistry and Laboratory Medicine, 2008
Standardization of cardiac troponin I (cTnI) measurement is important because of the central role for diagnosis of myocardial infarction. In blood, cTnI is present as a heterogeneous mixture of different molecular species. The analytical problem caused by this heterogeneity may be circumvented by recognition of a unique, invariant part of the molecule ...
M. Panteghini, D. M. Bunk, R. H. Christenson, A. Katrukha, R. A. Porter, H. Schimmel, L. Wang, J. R. Tate for the IFCC Working Group on Standardization of Troponin I.   +7 more
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Cardiac Troponin I [PDF]

, 1998
In striated muscle, the thin filament contains a protein complex containing three polypeptides: troponin C, I, and T, which are involved in calcium regulation. Troponin I (TnI) is the subunit of the troponin complex that inhibits actomyosin ATPase activity.
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Interaction of troponin I and troponin C: ¹⁹F NMR studies of the binding of the inhibitory troponin I peptide to turkey skeletal troponin C

Biochemistry and Cell Biology, 1991
We have used 19F nuclear magnetic resonance spectroscopy to study the interaction of the inhibitory region of troponin (TnI) with apo- and calcium(II)-saturated turkey skeletal troponin C (TnC), using the synthetic TnI analogue Nα-acetyl[19FPhe106]TnI(104–115)amide.
Paul J. Cachia, Brian D. Sykes, A. Patricia Campbell   +2 more
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The interaction of rabbit skeletal muscle troponin-T fragments with troponin-I

Canadian Journal of Biochemistry and Cell Biology, 1985
The interactions of troponin-I (Tn-I) with a variety of fragments spanning the length of the troponin-T (Tn-T) polypeptide chain have been reinvestigated at physiological ionic strength by affinity chromatographic, gel filtration, and circular dichroism methodologies.
Joyce R. Pearlstone, Lawrence B. Smillie
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Acute coronary ischemia: troponin I and T [PDF]

Vascular Medicine, 1999
Despite advances in diagnosis and management, ischemic heart disease remains the leading cause of death in the USA. Serum cardiac enzymes, one of the three fundamental criteria for establishing the diagnosis of myocardial infarction, are not specific for cardiac muscle and have a narrow time-window.
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Extensive Interactions Between Troponins C and I. Zero-Length Footnotes: Crosslinking Of Troponin I and Acetylated Troponin C

Biochemistry, 1995
Interactions between troponin C (TnC) and troponin I (TnI) play an important role in the Ca(2+)-dependent regulation of vertebrate striated muscle contraction. Earlier studies have led to the proposal that the "inhibitory region" (residues 96-116) of TnI binds to an alpha-helical segment of TnC comprising residues 89-100 in the nonregulatory, C ...
John H. Collins, John Gergely, Tomoyoshi Kobayashi, Zenon Grabarek   +3 more
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Troponin I and colonoscopy [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2009
J A Tovey, A Brain, A T George
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Cardiac Troponin I in Asphyxiated Neonates

Neonatology, 2006
<i>Background:</i> Cardiac troponins T (cTnT) and I (cTnI) are <i>well-established </i>markers in detecting myocardial ischemic damage in adults. Perinatal asphyxia is associated with cardiac dysfunction. <i>Objectives:</i> To evaluate serum concentrations of cTnI in asphyxiated neonates and to investigate whether ...
Trevisanuto D., Picco G., Golin R., Doglioni N., Altinier S., Zaninotto M., Zanardo V.   +6 more
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Analytical Evaluation of an Automated Immunoassay for Cardiac Troponin I: The Vidas Troponin I Assay

Clinical Chemistry and Laboratory Medicine, 2003
Cardiac troponin I (cTnI) is a sensitive and specific biochemical marker of myocardial damage. We assessed the analytical performance of the Vidas Troponin I assay (Biomerieux). Controls and serum pools were used to determine the precision, analytical sensitivity and linearity; 97.5 and 99.5 percentiles concentrations were determined from the reference
Lucia Varraso, Francesca Di Serio, Gabriella Serio, Paolo Trerotoli, N Pansini   +4 more
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Diagnosis of myocardial infarction: Cardiac troponin I or troponin T?

Clinical Biochemistry, 2014
Nicholas L. Mills, Kuan Ken Lee, Anoop S V Shah   +2 more
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