Results 81 to 90 of about 5,930 (185)
FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier
, 2013 We report the first documented case of an atypical form of transient reactive papulotranslucent acrokeratoderma (TRPA) in a patient heterozygous for the ΔF508 CFTR(cystic fibrosis transmembrane conductance regulator) mutation. TRPA represents a condition
Baquerizo, Katherine +4 more
core +1 more source
eLife, 2016 Adequate responses to noxious stimuli causing tissue damages are essential for organismal survival. Class IV neurons in Drosophila larvae are polymodal nociceptors responsible for thermal, mechanical, and light sensation. Importantly, activation of Class
Shin-Ichiro Terada +5 more
doaj +1 more source
Evolution of multi-enzyme complexes: the case of tryptophan synthase.
, 2006 The prototypical tryptophan synthase is a stable heterotetrameric alpha-beta beta-alpha complex. The constituting TrpA and TrpB1 subunits, which are encoded by neighboring genes in the trp operon, activate each other in a bi-directional manner. Recently,
Leopoldseder, Sonja +2 more
core +1 more source
Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction
, 2019 Tryptophan synthase (TS) is a heterotetrameric alpha beta beta alpha complex. It is characterized by the channeling of the reaction intermediate indole and the mutual activation of the alpha-subunit TrpA and the beta-subunit TrpB via a complex allosteric
Merkl, Rainer +4 more
core +1 more source
, 2020 Limited longitudinal evidence of the predictors of physical activity (PA) patterns over time exists, particularly among high-risk groups such as women living in socioeconomically disadvantaged areas.
Timperio, A (15503519) +6 more
core
, 2010 In this article, associations between individual, social, and environmental factors and physical activity among 3,669 women (18-45 years) living in socioeconomically disadvantaged urban and rural areas were compared.
Kylie Ball +3 more
core +1 more source
Plant-Derived Tick Repellents Activate the Honey Bee Ectoparasitic Mite TRPA1
Cell Reports, 2015 We have identified and characterized the TRPA1 channel of Varroa destructor (VdTRPA1), a major ectoparasitic mite of honey bee. One of the two VdTRPA1 isoforms, VdTRPA1L, was activated by a variety of plant-derived compounds, including electrophilic ...
Guangda Peng +6 more
doaj +1 more source
Journal of Biological Chemistry, 1987 The separate alpha and beta polypeptides of the tryptophan synthetase of bacteria are represented in fungi by a fusion polypeptide in which the first third is homologous to bacterial alpha chains and the remainder is homologous to bacterial beta chains. In the yeast polypeptide, a short nonhomologous "connector" joins the two homologous segments.
C, Yanofsky +3 more
openaire +2 more sources
Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint
, 2019 The alpha beta beta alpha tryptophan synthase (TS), which is part of primary metabolism, is a paradigm for allosteric communication in multienzyme complexes.
Reinhard Sterner +7 more
core +1 more source