Results 71 to 80 of about 5,930 (185)
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Analysis of Allostery in the Tryptophan Synthase Complex by Horizontal and Vertical Approaches [PDF]
The tryptophan synthase (TS) is a linear complex that catalyzes the last two steps of tryptophan biosynthesis in primary metabolism. It is a model system for subunit interactions in multi-enzyme complexes with a long-standing history of research.
Schupfner, Michael
core +1 more source
Gene Deletion by Fluorescence-Reported Allelic Exchange Mutagenesis in
Although progress in Chlamydia genetics has been rapid, genomic modification has previously been limited to point mutations and group II intron insertions which truncate protein products.
Konrad E. Mueller +2 more
doaj +1 more source
The inverted F‐type ZnWO4/In2S3 heterojunction enables efficient charge separation and retention of strong oxidative capability through interfacial electric field regulation, leading to non‐toxic degradation of contaminants for sustainable water treatment.
Yanxian Jin +9 more
wiley +1 more source
Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which ...
Naraporn Somboonna +4 more
doaj +1 more source
Co‐cultivation screening of 116 duckweed‐associated bacteria revealed isolates that enhanced Wolffia globosa biomass up to 77.75%, with Pseudomonas toyotomiensis W5–11 increasing dry weight 3.18‐fold and chlorophyll content 2.75‐fold, demonstrating their potential as biofertilisers for sustainable duckweed production.
Sirapat Kettongruang +2 more
wiley +1 more source
Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues
The performance of commercial antibodies against the ion channels TRPV1 and TRPA1 was systematically evaluated, given their key roles in nociception and inflammation. Sensitivity and specificity were assessed using immunocytochemistry, immunohistochemistry, and western blotting in heterologous and native expression systems.
M. de las Casas +6 more
wiley +1 more source
Abstract How can anthropologists ensure the accuracy of the statements they make in their publications, especially in an era of ever increasing budgetary and bureaucratic pressures that limit the duration of fieldwork? What should the role of language abilities be in this context and to what degree is it necessary to learn the language of the place ...
Mark Collins, Tukul Walla Kaiku
wiley +1 more source
Evolution of Multi-Enzyme Complexes: The Case of Tryptophan Synthase†
The prototypical tryptophan synthase is a stable heterotetrameric α−ββ−α complex. The constituting TrpA and TrpB1 subunits, which are encoded by neighboring genes in the trp operon, activate each other in a bi-directional manner.
Stefan Hettwer (521413) +2 more
core +1 more source
Background The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give information about the pattern and ...
Krüger Jana +3 more
doaj +1 more source

