Results 51 to 60 of about 5,930 (185)

Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel

Cell Reports, 2015
Temperature profoundly affects aging in both poikilotherms and homeotherms. A general belief is that lower temperatures extend lifespan, whereas higher temperatures shorten it.
Bi Zhang, Rui Xiao, Elizabeth A. Ronan, Yongqun He, Ao-Lin Hsu, Jianfeng Liu, X.Z. Shawn Xu   +6 more
doaj   +1 more source

Evolutionary conservation and changes in insect TRP channels

BMC Evolutionary Biology, 2009
Background TRP (Transient Receptor Potential) channels respond to diverse stimuli and thus function as the primary integrators of varied sensory information.
Tominaga Makoto, Kohno Keigo, Sokabe Takaaki, Matsuura Hironori, Kadowaki Tatsuhiko   +4 more
doaj   +1 more source

Directed evolution of ( )8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase -subunit

, 2012
Phosphoribosylanthranilate (PRA) isomerase (TrpF) and tryptophan synthase -subunit (TrpA) are ()(8)-barrel enzymes that are involved in the biosynthesis of tryptophan. They contain a conserved phosphate binding site, which indicates a common evolutionary
Evran, Serap, Evran, S., Telefoncu, Azmi, Sterner, R., Telefoncu, A., Sterner, Reinhard   +5 more
core   +2 more sources

Genetic Transformation of a C. trachomatis Ocular Isolate With the Functional Tryptophan Synthase Operon Confers an Indole-Rescuable Phenotype

Frontiers in Cellular and Infection Microbiology, 2018
Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this tissue
Colette Elizabeth O'Neill, Rachel Jane Skilton, Sarah Ann Pearson, Simone Filardo, Patiyan Andersson, Ian Nicholas Clarke   +5 more
doaj   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Behavioral Aversion to AITC Requires Both Painless and dTRPA1 in Drosophila

Frontiers in Neural Circuits, 2018
There has been disagreement over the functional roles of the painless gene product in the detection and subsequent behavioral aversion to the active ingredient in wasabi, allyl isothiocyanate (AITC).
Samantha J. Mandel, Madison L. Shoaf, Jason T. Braco, Wayne L. Silver, Wayne L. Silver, Erik C. Johnson, Erik C. Johnson   +6 more
doaj   +1 more source

Quality and Shelf Life of Labneh as Affected by Using some Essential Oils [PDF]

Journal of Food and Dairy Sciences, 2019
Improving the keeping quality of labneh by means of using essential oils (EO) was the objective of the present study. Cinnamon, cumin and mint oils were added separtly at level of 0.5, 1.0, and 1.5 % (v ̸ w) to the prepared traditional labneh.
H. Hattem, Sala E. Abo El-kher, R. EL-Ahwal   +2 more
doaj   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, Volume 41, Issue 10, Page 1105-1118, October 2026.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Indole produced during dysbiosis mediates host–microorganism chemical communication

eLife, 2023
An imbalance of the gut microbiota, termed dysbiosis, has a substantial impact on host physiology. However, the mechanism by which host deals with gut dysbiosis to maintain fitness remains largely unknown.
Rui-Qiu Yang, Yong-Hong Chen, Qin-yi Wu, Jie Tang, Shan-Zhuang Niu, Qiu Zhao, Yi-Cheng Ma, Cheng-Gang Zou   +7 more
doaj   +1 more source