Results 51 to 60 of about 41,565 (180)
Genetics‐Based Targeting Strategies for Precise Neuromodulation
Advanced Science, Volume 12, Issue 28, July 24, 2025.In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He +11 more
wiley +1 more source
ChemMedChem, Volume 20, Issue 12, June 17, 2025.The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska +5 more
wiley +1 more source
ChemMedChem, Volume 20, Issue 6, March 15, 2025.This review goes beyond the famous MD‐2/TLR4‐mediated recognition of LPS, pointing the attention on other immune detection systems and their impact on human physiology and pathology. Understanding these additional pathways is key for the development of pharmacologically active molecules to modulate the immune response and to conceive new strategies to ...
Stefania De Chiara +7 more
wiley +1 more source
Neuroprotective effects of Lycium barbarum polysaccharides against rat hippocampal apoptosis induced by chronic intermittent hypoxia [PDF]
, 2012 Poster presentationWe have shown neuronal apoptosis in the hippocampus of rats exposed to chronic intermittent hypoxia mimicking severe conditions of obstructive sleep apnea (OSA) syndrome in patients [1].
Fung, ML, Lam, CS, Tipoe, GL
core
A polycystin-type transient receptor potential (Trp) channel that is activated by ATP. [PDF]
, 2016 ATP and ADP are ancient extra-cellular signalling molecules that in Dictyostelium amoebae cause rapid, transient increases in cytosolic calcium due to an influx through the plasma membrane.
Kay, Robert R, Traynor, David
core +2 more sources
Thermosensory Roles of G Protein‐Coupled Receptors and Other Cellular Factors in Animals
BioEssays, Volume 47, Issue 3, March 2025.Recent studies have revealed GPCR functions in temperature sensation. This article introduces dual thermosensing via GPCRs and TRP channels associated with the intracellular signaling components and cellular factors such as lipid interactions and pH changes, highlighting the complexity of the temperature sensing mechanism.
Kohei Ohnishi, Takaaki Sokabe
wiley +1 more source
Molecular mechanisms involved in the generation of calcium signals In insulin secreting cells. [PDF]
, 2014 Intracellular Ca 2+ regulates diverse cellular functions in almost all the cells. In the pancreatic ß-cells, Ca 2+ signals are critical for insulin secretion. An increase in the cytoplasmic free Ca 2+ concentration ([Ca 2+ ]i) triggers insulin secretion.
Krishnan, Kalaiselvan
core
TRP Ion Channels: From Distribution to Assembly [PDF]
, 2018 Transient receptor potential (TRP) ion channel superfamily is widely distributed from neuronal to non-neuronal tissues by serving as cellular sensors via interacting with a wide spectrum of physical and chemical stimuli.
Cheng, Wei
core +2 more sources
Thermo‐TRP regulation by endogenous factors and its physiological function at core body temperature
Physiological Reports, Volume 13, Issue 1, January 2025.Abstract Transient receptor potential (TRP) channels with temperature sensitivities (thermo‐TRPs) are involved in various physiological processes. Thermo‐TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic ...
Makiko Kashio
wiley +1 more source
Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel [PDF]
, 2014 The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent studies reported that mutations in TRPV4, including some in its ankyrin repeat domain (
Gaudet, Rachelle +3 more
core +2 more sources