Results 41 to 50 of about 3,392 (133)

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, Volume 37, Issue 33, August 21, 2025.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics [PDF]

, 2016
Novel approaches towards cancer therapy are urgently needed. One approach might be to target ion channels mediating Ca²+ entry because of the critical roles played by Ca²+ in many cell types, including cancer cells.
A Arcangeli, A Fleckenstein, A Riccio, B Kumar, B Minke, B Vannier, B Zeng, C Carson, C Sourbier, C Strubing, CE Paulsen, CX Bai, CY Kuang, D Veliceasa, David J. Beech, DD McKemy, DE Clapham, DJ Beech, E Al-Shawaf, F Antigny, F Zheng, GR Monteith, H Wei, Hannah J. Gaunt, HB Song, HN Jiang, J Abramowitz, J Li, JC Herve, JM Richter, JM Richter, KD Phelan, KN Westlund, L Birnbaumer, L Radtke, M Liao, M Miller, M Tominaga, MC Mohl, MJ Berridge, N Damann, N Prevarskaya, Naveen S. Vasudev, NS Vasudev, P Sukumar, PC Yu, PD Wes, PK Flemming, R Ratnayake, RS Bon, S Jung, S Orrenius, SE Jordt, SZ Xu, SZ Xu, SZ Xu, T Schaldecker, T Wang, TA Stewart, V Caropreso, VV Tsvilovskyy, X Ma, X Ma, X Ma, Y Akbulut, Y Majeed, YF Chen, YR Park   +67 more
core   +2 more sources

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Ocular transient receptor potential channel function in health and disease [PDF]

, 2015
Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca2+ transients that in turn induce responses essential for cell function and adaptation.
Mergler, Stefan, Okada, Yuka, Reinach, Peter S., Saika, Shizuya   +3 more
core   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we?

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
This review goes beyond the famous MD‐2/TLR4‐mediated recognition of LPS, pointing the attention on other immune detection systems and their impact on human physiology and pathology. Understanding these additional pathways is key for the development of pharmacologically active molecules to modulate the immune response and to conceive new strategies to ...
Stefania De Chiara, Luca De Simone Carone, Roberta Cirella, Emanuela Andretta, Alba Silipo, Antonio Molinaro, Marcello Mercogliano, Flaviana Di Lorenzo   +7 more
wiley   +1 more source

Thermosensory Roles of G Protein‐Coupled Receptors and Other Cellular Factors in Animals

BioEssays, Volume 47, Issue 3, March 2025.
Recent studies have revealed GPCR functions in temperature sensation. This article introduces dual thermosensing via GPCRs and TRP channels associated with the intracellular signaling components and cellular factors such as lipid interactions and pH changes, highlighting the complexity of the temperature sensing mechanism.
Kohei Ohnishi, Takaaki Sokabe
wiley   +1 more source

TRPV4: Molecular Conductor of a Diverse Orchestra [PDF]

, 2016
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz ( Nat Cell Biol 2: 695 –702, 2000) and Liedtke ( Cell 103: 525–535, 2000).
Cibelli, Mario, McGeown, J. Graham, Nagy, Istvan, Nilius, Bernd, Urban, Laszlo, White, John P M   +5 more
core   +1 more source

Thermo‐TRP regulation by endogenous factors and its physiological function at core body temperature

Physiological Reports, Volume 13, Issue 1, January 2025.
Abstract Transient receptor potential (TRP) channels with temperature sensitivities (thermo‐TRPs) are involved in various physiological processes. Thermo‐TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic ...
Makiko Kashio
wiley   +1 more source