Results 161 to 170 of about 6,680,071 (237)

Integrated microanatomy and microstructure of the maxillary tooth plate reveal a reinforced feeding system and tougher diet in Late Triassic Hyperodapedontinae (Rhynchosauria, Archosauromorpha)

The Anatomical Record, EarlyView.
Abstract Hyperodapedontine rhynchosaurs possessed a unique oral apparatus, long interpreted as an adaptation for processing abrasive and resistant plant material. However, the microanatomical and histological evidence supporting this interpretation remains poorly documented.
Caio A. Scartezini, Pedro L. B. Pruciano, Brodsky D. M. Farias, Marina B. Soares   +3 more
wiley   +1 more source

Pelvic breadth and juvenile locomotor energetics: Implications for the obstetrical dilemma hypothesis across human growth in past and present humans

The Anatomical Record, EarlyView.
Abstract The obstetrical dilemma hypothesis (ODH) proposes an evolutionary trade‐off between obstetric requirements and locomotor performance. However, whether external pelvic breadth measures influence walking energetics during human growth remains poorly understood.
Guillermo Zorrilla‐Revilla, Olalla Prado‐Nóvoa, Kevin P. Davy, José Miguel Carretero, Rebeca García‐González   +4 more
wiley   +1 more source

Osteohistological evidence for terrestrial adaptation and an extended growth period in mekosuchine crocodylians and its potential role in their extinction

The Anatomical Record, EarlyView.
Abstract The Australasian crocodylian fossil record is dominated by the extinct endemic clade Mekosuchinae, with known members spanning the Eocene‐to‐Holocene. This diverse clade exhibited high morphological disparity, from early members superficially similar to Crocodylus, to more terrestrial forms later in the clade's evolutionary history.
Devin K. Hoffman, Cecily S. C. Nicholl, Oliver Bradley, Sreya Magar, Marie Sofia Sebaratnam, Alexandra Houssaye, Ryan N. Felice, Adam M. Yates, Stephen F. Poropat, Philip D. Mannion   +9 more
wiley   +1 more source

ZBED6 Knockout Promotes Skeletal Muscle Development in Bama Pigs by Relieving Transcriptional Repression of CDKN1A

Animal Research and One Health, EarlyView.
Integrated transcriptomic and functional analyses identify CDKN1A as a direct target of ZBED6 in Bama pigs. ZBED6 knockout relieves transcriptional repression of CDKN1A, thereby promoting myogenic differentiation and skeletal muscle development.
Yitian Ma, Xiu Lin, Pengtao Yuan, Yabin Pu, Yuehui Ma, Zixiao Jiang, Lin Jiang, Chongyang Li, Dandan Wang   +8 more
wiley   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Valorization of Textile Waste: Enzymatic Upcycling of Terephthalic Acid Toward a Sustainable PET Value Chain

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT The rapid expansion of the global textile industry, driven by the fast‐fashion paradigm, which is characterized by low‐cost, short‐lived garments made from inexpensive synthetic fibers, has intensified environmental pressures through increased waste generation, resource depletion, microplastic pollution, and greenhouse gas emissions ...
Fares Al‐Ostoot, Loredano Pollegioni, Elena Rosini   +2 more
wiley   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Studies of the effects of different treatments on the metabolizable energy value of wheat

, 1968
Four successive experiments were carried out to study the effects of different treatments on the nutritive quality of 4 samples of wheat. The treatments used were autoclaving, freezing, water-soaking, acid-soaking, boiling in water, and combinations of ...
El-Lakany, Safaa
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