Results 101 to 110 of about 891,454 (299)

Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT

Health and Social Care Delivery Research
Background Staff sickness absenteeism and presenteeism (attending work while unwell) incur high costs to the NHS, are associated with adverse patient outcomes and have been exacerbated by the COVID-19 pandemic.
Rachel Adams, Rachel E Jordan, Alisha Maher, Peymane Adab, Timothy Barrett, Sheriden Bevan, Lucy Cooper, Ingrid DuRand, Florence Edwards, Pollyanna Hardy, Ciara Harris, Nicola R Heneghan, Kate Jolly, Sue Jowett, Tom Marshall, Margaret O’Hara, Christopher Poyner, Kiran Rai, Hugh Rickards, Ruth Riley, Natalie Ives, Steven Sadhra, Sarah Tearne, Gareth Walters, Elizabeth Sapey   +24 more
doaj   +1 more source

Hover performance tests of baseline metal and Advanced Technology Blade (ATB) rotor systems for the XV-15 tilt rotor aircraft [PDF]

Rotor hover performance data were obtained for two full-scale rotor systems designed for the XV-15 Tilt Rotor Research Aircraft. One rotor employed the rectangular planform metal blades (rotor solidity = 0.089) which were used on the initial flight ...
Alexander, H., Bartie, K., Bishop, H., Lamon, S., Mcveigh, M.   +4 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

An investigation of the relation between the number of children and education in Italy [PDF]

In this paper we have investigated the impact of the level of education on the number of children in Italy. We have selected 1,490 families from the 1997- 2005 Longitudinal Investigation on Italian Families (ILFI) dataset.
Aldieri, Luigi, Vinci, Concetto Paolo
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural safety uncertainties in codes of practice for reinforced concrete

, 2004
The limit-state design approach, currently used in codified design of concrete structures reinforced with steel reinforcement, is based on semi-probabilistic procedures.
Neocleous, K., Pilakoutas, K., Waldron , P.   +2 more
core