Results 231 to 240 of about 456,372 (322)
Halofuginone is a Molecular Glue Degrader of Integrin β4
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
A novel Hankel norm approximation-based AGC for a hydro-dominated power system. [PDF]
Naqvi S +4 more
europepmc +1 more source
Influences of Short-Wave Truncations to Spectral Energy Budget in Hall MHD Turbulence
Hideaki Miura
openalex +2 more sources
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang +9 more
wiley +1 more source
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries. [PDF]
Ling YH, Liang C, Wang S, Wu C.
europepmc +1 more source
First natural transverse frequency of truncated cone and wedge beams
Vazgen Bagdasaryan +4 more
openalex +1 more source
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño +5 more
wiley +1 more source
A Multi-Step Grasping Framework for Zero-Shot Object Detection in Everyday Environments Based on Lightweight Foundational General Models. [PDF]
Li R, Zhang T, Zou Y.
europepmc +1 more source

