Results 201 to 210 of about 1,845,672 (246)

From perceived typicality of in-vehicle stylistic cues to autonomous vehicle acceptance: the roles of perceived behavioral control and trust. [PDF]

Front Psychol
Pan J, Qin Y, Zhu Y, Chen K, Chen M.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Characterising Hepatitis D Virus in the UK From 2011 to 2021. [PDF]

J Viral Hepat
Simmons R, Ijaz S, Jackson R, Jack K, Mulongeni R, Raghu R, Riddell A, Elsharkawy A, Uriel A, Koffas A, Chaika A, Lawson A, Cole A, McEwan A, Brown A, Stone B, Levick C, Byrne D, Forton D, MacDonald D, Forde D, Nastouli E, Barnes E, Sumner E, Page E, Carey I, Vilar FJ, Maggs J, Collier J, Shepherd J, Agarwal K, Bicknell K, Ala K, Dear K, Ratcliffe L, Bruce M, Zhang H, Rivett L, Maes M, Ankcorn M, Aldersley M, Prince M, Lemoine M, Foxton M, Wright M, Cramp M, Wiselka M, Easom N, Richardson P, Gunson R, Herbert R, Blackwell R, Jelley R, Aspinall R, Simpson R, Clewes R, Ahmad S, Mcpherson S, Ryder S, Verma S, Lampejo T, Sathyanarayana V, Gelson W, Leeman D, Desai M, Mandal S, Kennedy PT, Irving WL.   +67 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Perceived Performance of Community Two Committees and Satisfaction with Urban Infectious Disease Governance: The Mediating Roles of Government Trust and Public Participation. [PDF]

Risk Manag Healthc Policy
Huang W, Li H, Sun Y, Zhang Y, Gao X, Chen C, Hao Y, Wu Q, Zhu Z, Liu H.   +9 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Governing algorithms, empowering people: how ethical AI oversight shapes trust, technostress, and employee autonomy in AI-enabled HRM. [PDF]

Front Artif Intell
Patnaik T, Gnankob RI, Nanda NS.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source