Results 81 to 90 of about 4,285,067 (308)

Effects of concurrent chloroquine and ethanol administration on the rat kidney morphology

The Pan African Medical Journal, 2018
INTRODUCTION: The use of antimalarial chloroquine in malaria-endemic regions of Africa is rampant and it is not uncommon to find individuals taken the drug concurrent with alcohol.
Abdurrahman Abdulkadir, Ejikeme Felix Mbajiorgu, Trust Nyirenda   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Trust, regulatory processes and NICE decision-making: Appraising cost-effectiveness models through appraising people and systems. [PDF]

, 2015
This article presents an ethnographic study of regulatory decision-making regarding the cost-effectiveness of expensive medicines at the National Institute for Health and Care Excellence (NICE) in England.
Abraham J, Abraham J, Bodewitz H, Calnan M, Ferhana Hashem, Giddens A, Habermas J, Khodyakov D, Luhmann N, Luhmann N, Luhmann N, MacKenzie G, Michael Calnan, Möllering G, Patrick Brown, Shapin S, Simon H, Thompson C, Will C   +18 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

How managers can build trust in strategic alliances: a meta-analysis on the central trust-building mechanisms [PDF]

, 2016
Trust is an important driver of superior alliance performance. Alliance managers are influential in this regard because trust requires active involvement, commitment and the dedicated support of the key actors involved in the strategic alliance.
A Ariño, A Joshi, A Parkhe, A Parkhe, A Parkhe, A Rindfleisch, A Rus, A Wong, A Zaheer, A Zaheer, A Zaheer, AC Inkpen, AC Inkpen, AI Huffcutt, B Anand, Carolin Decker, D Eden, D Rousseau, DA Harrison, DA Levinthal, DF Jennings, DJ McAllister, DM Rousseau, E Anderson, E Anderson, EM Whitener, FT Rothaermel, G Duysters, G Hofstede, I Geyskens, I Geyskens, J Bleeke, J Cohen, JB Heide, JE Hunter, JE Hunter, JH Dyer, JM Cortina, JM Geringer, KJ Mayer, L Poppo, L Poppo, L Rosenkopf, LG Zucker, M Bensaou, M Borenstein, M Fichman, M Zollo, Martina Lütkewitte, Matthias Meier, MJ Robson, MJ Robson, MW Lipsey, OE Williamson, OE Williamson, P Kale, P Kale, PS Ring, R Bachmann, R Bhattacharya, R Gulati, R Gulati, R Lunnan, R Rosenthal, R Seppänen, RC Mayer, RD Ireland, RM Kramer, RM Kramer, S Duval, S Ganesan, S Zaheer, SH Park, SP Deshpande, SS Lui, T Khanna, T Mellewigt, Thomas Mellewigt, TK Das, TK Das, Z Cao   +80 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Enacting Trust [PDF]

, 2012
Small and removed from the Spanish mainland, the Enclave of Ceuta has always depended on flows of goods and labour out of the Moroccan hinterland, with individuals from different ethnic and religious groups forming informal, flexible and personal ...
Campbell, Brian
core  

Reflections on trusting trust [PDF]

Communications of the ACM, 1984
To what extent should one trust a statement that a program is free of Trojan horses? Perhaps it is more important to trust the people who wrote the software.
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source