Results 41 to 50 of about 768,420 (292)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Attitudes toward Telling the Truth to Cancer Patients in Iran: A Review Article

International Journal of Hematology-Oncology and Stem Cell Research, 2016
Background: Patientsgenerallyhave the right to be informed of their condition,but the debate over the issue of truth disclosure is still present. The attempt of this study is to review the approaches toward truth- telling to cancer patients in Iran ...
Ali Karimi Rosveh, Reza Nabi Amjad, Javad Karimi Rosveh, Davood Rasouli   +3 more
doaj  

Disclosure of true medical information: the case of Bangladesh

BMC Medical Ethics
Background Truth-telling in health care is about providing patients with accurate information about their diagnoses and prognoses to enable them to make decisions that can benefit their overall health.
Sanwar Siraj, Kristien Hens, Yousuf Ali
doaj   +1 more source

Truth-Telling in Disclosing a Schizophrenia Diagnosis to Families: Doctors’ Ethical Considerations in a Psychiatric Hospital

Psychiatry International
Disclosing a schizophrenia diagnosis presents significant ethical dilemmas due to stigma, caregiving burdens, and cultural norms. This study explored psychiatrists’ ethical considerations when disclosing this diagnosis to family members in Indonesia ...
Enrico Adhitya Rinaldi, Retna Siwi Padmawati, Yayi Suryo Prabandari   +2 more
doaj   +1 more source

Truth Telling as an Element of Ethical Behaviour and Professional Commitment in Dentistry: A Case Study Assessing Non-Disclosure Action

Canadian Journal of Bioethics, 2022
Being truthful with patients is a critical foundation of the doctor-patient relationship and is fundamental to development of trust. A professional commitment to truth telling may sometimes contradict other principles of bioethics, which may challenge ...
Leyla Sadighpour, Greg S. Anderson
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The “CONNECT” Protocol: Delivering Bad News by Phone or Video Call

International Journal of General Medicine, 2022
Krzysztof Sobczak Department of Sociology Medicine and Social Pathology, Medical University of Gdansk, Gdansk, PolandCorrespondence: Krzysztof Sobczak, Department of Sociology Medicine and Social Pathology, Medical University of Gdansk, Tuwima 15 Str ...
Sobczak K
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source