Results 51 to 60 of about 227,718 (306)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Professional liability insurance and medical error disclosure
Swiss Medical Weekly, 2015 QUESTION UNDER STUDY: To examine medicolegal stakeholders’ views about the impact of professional liability insurance in Switzerland on medical error disclosure. METHODS: Purposive sample of 23 key medicolegal stakeholders in Switzerland from
Stuart McLennan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Récit et vérité chez Tzvetan Todorov
Ticontre: Teoria Testo Traduzione, 2014 L’article se propose d’étudier certains aspects de la relation entre récit et vérité dans l’œuvre critique de Tzvetan Todorov. Pour lui la recherche de la vérité a toujours été étroitement liée à son intérêt inlassable pour le récit, pour l’acte de ...
Miriana Alexandrova Yanakieva
doaj +3 more sources
The question concerning the environment: a Heideggerian approach to environmental philosophy : a thesis presented in partial fulfillment of the requirements for the degree of Master of Arts in Philosophy at Massey University [PDF]
, 2008 This thesis will engage with the thinking of Martin Heidegger in order to show that our environmental problems are the necessary consequences of our way of 'knowing' the world.
Bowyer, Lynne
core
What science can teach us about “Enhanced Interrogation” [PDF]
, 2017 No abstract ...
Duke, Misty C., Van Puyvelde, Damien
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
"The Speech of Dasein: Heidegger and Quotidian Discourse" [PDF]
, 2017 In § 35 of Sein und Zeit Heidegger’s denunciation of Gerede, idle talk, is confident and scathing. It sounds so sinister and threatening. What could Heidegger be talking about? One could cite numerous fictional characters (e.g., Pecksniff, Mrs.
Gelley, Alexander
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Constructing Ricoeur’s Hermeneutical Theory of Truth [PDF]
, 2016 While there are several moments throughout his career when Ricoeur devotes attention to the problem of truth—for example, in History and Truth, his conception of manifestation in his biblical hermeneutics, and when discussing convictions and non ...
Mei, Todd
core +1 more source