Results 71 to 80 of about 17,268 (260)
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Truth, Plurality, and Political Phenomenology: Hannah Arendt’s Socrates
FilozofiaThis paper examines Hannah Arendt’s Socrates. I argue that Arendt construes Socrates as a model of the compatibility of philosophy and politics. This model uniquely articulates this compatibility through a hermeneutic-phenomenological approach, where ...
Antoine Pageau-St-Hilaire
doaj +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Delivering bad news: patient's perspective and opinions
Patient Preference and Adherence, 2018 Krzysztof Sobczak, Katarzyna Leoniuk, Agata Janaszczyk Department of Social Medicine and Social Pathology, Medical University of Gdansk, Gdansk, Poland Purpose: The aim of our research was to gain knowledge about patients’ opinions, experiences ...
Sobczak K, Leoniuk K, Janaszczyk A
doaj
Frontiers in MedicineIntroductionBreaking bad news is a critical yet challenging aspect of healthcare that requires effective communication skills, empathy, and cultural sensitivity.
Abdulla Ahmad A. A. Yousuf +7 more
doaj +1 more source
Understanding expert testimony on child sexual abuse denial after New Jersey v. J.L.G.: Ground truth, disclosure suspicion bias, and disclosure substantiation bias. [PDF]
Behav Sci Law, 2020 Lyon TD, Williams S, Stolzenberg SN.
europepmc +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Journal of Indian Academy of Oral Medicine and RadiologyBackground: Bad news refers to a circumstance where an individual’s mental or physical health is at risk, and they experience a sense of hopelessness.
Kalai E. Ganesan +5 more
doaj +1 more source