Results 91 to 100 of about 227,718 (306)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Making the FTC ☺: An Approach to Material Connections Disclosures in the Emoji Age [PDF]

open access: yes, 2018
In examining the rise of influencer marketing and emoji’s concurrent surge in popularity, it naturally follows that emoji should be incorporated into the FTC’s required disclosures for sponsored posts across social media platforms.
Sauerborn, Christina
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Commentary: Disclosure in Oncology—To Whom Does the Truth Belong?

open access: yesThe Oncologist, 2009
Learning ObjectivesSummarize the meaning of the term “therapeutic nondisclosure” in the context of medical oncology practice. Classify the reasons for variations in disclosure practices around the world. Develop strategies for approaching a conversation about disclosure that respects the rights and needs of the patient and family.This article is ...
William A, Wood   +2 more
openaire   +2 more sources

Of Cherries, Fudge, and Onions: Science and Its Courtroom Perversion [PDF]

open access: yes, 2001
The thesis of this article is that the Supreme Court decision in Daubert v. Merrell Dow Pharmaceuticals, Inc.\u27s focus on the scientific method, however rigorously applied, invites certain classes of abuses. There are instances in which evidence can be
Conley, John M., Peterson, David W.
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Lies and Medicine

open access: yesSouth African Family Practice, 1992
No abstract available.
Domeena C. Renshaw
doaj   +1 more source

[Truth disclosure to patients diagnosed with cancer].

open access: yesAtencion primaria, 1996
To find the sort of information given to cancer patients in PC and the factors which affect the disclosure of the diagnosis.A descriptive crossover study, carried out through a personal interview.A county hospital with no oncology service.All those patients with cancer (histologically confirmed) admitted to the hospital during April and May 1993.Each ...
J E, Cimas Hernando   +5 more
openaire   +1 more source

The genealogical jigsaw puzzle - a missing piece? the right to know for A.I.D. children [PDF]

open access: yes, 2004
This paper examines current UK legal regulation relating to the provision of genetic background information to children born by donor insemination (Dl) and argues in favour of changes to the existing law - the Human Fertilisation and Embryology Act 1990.
Henaghan, Caroline
core  

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