Results 101 to 110 of about 227,718 (306)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Truth, Plurality, and Political Phenomenology: Hannah Arendt’s Socrates

open access: yesFilozofia
This paper examines Hannah Arendt’s Socrates. I argue that Arendt construes Socrates as a model of the compatibility of philosophy and politics. This model uniquely articulates this compatibility through a hermeneutic-phenomenological approach, where ...
Antoine Pageau-St-Hilaire
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Common Principles and Multiculturalism [PDF]

open access: yesJournal of Medical Ethics and History of Medicine, 2009
Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not.
Farzaneh Zahedi, Bagher Larijani
doaj   +1 more source

Delivering bad news: patient's perspective and opinions

open access: yesPatient Preference and Adherence, 2018
Krzysztof Sobczak, Katarzyna Leoniuk, Agata Janaszczyk Department of Social Medicine and Social Pathology, Medical University of Gdansk, Gdansk, Poland Purpose: The aim of our research was to gain knowledge about patients’ opinions, experiences ...
Sobczak K, Leoniuk K, Janaszczyk A
doaj  

Health professionals’ views and experiences of breaking bad news in the Eastern Mediterranean Region: a scoping review

open access: yesFrontiers in Medicine
IntroductionBreaking bad news is a critical yet challenging aspect of healthcare that requires effective communication skills, empathy, and cultural sensitivity.
Abdulla Ahmad A. A. Yousuf   +7 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Breaking the Bad News to Patients: Dental Students’ Perception and Practice – A Cross Sectional Survey

open access: yesJournal of Indian Academy of Oral Medicine and Radiology
Background: Bad news refers to a circumstance where an individual’s mental or physical health is at risk, and they experience a sense of hopelessness.
Kalai E. Ganesan   +5 more
doaj   +1 more source

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