Results 61 to 70 of about 400 (115)

Advances in attenuating opioid-induced respiratory depression: A narrative review. [PDF]

Medicine (Baltimore)
Fan YZ, Duan YL, Chen CT, Wang Y, Zhu AP.   +4 more
europepmc   +1 more source

(343) Oliceridine (TRV130), a novel μ receptor G protein pathway selective modulator (μ-GPS), demonstrates a predictable relationship between plasma concentrations and pain relief. II: simulation of potential dosing regimens using a pharmacokinetic/pharmacodynamic (PK/PD) model [PDF]

The Journal of Pain, 2016
M. Fossler, B. Sadler, C. Farrell, D. Burt, M. Pitsiu, F. Skobieranda, D. Soergel   +6 more
openaire   +1 more source

Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: A translational scoping review protocol. [PDF]

PLoS One
Zhang Y, Chen Q, Zhou Y, Zeng Q, Cui H, Zhou Y.   +5 more
europepmc   +1 more source

Unraveling allosteric signaling of G protein-coupled receptors (GPCRs) by single-molecule fluorescence. [PDF]

Biophys Rev
Agbadaola MT, Hilger D, Keller S, Krainer G.   +3 more
europepmc   +1 more source

Mechanistic Insights into G Protein-Biased κ-Opioid Receptor Signaling Using Dual-Charged Naltrexamine Amides. [PDF]

J Med Chem
Doering NP, Puls K, Diceglie M, Meraner A, Hentsch A, Hongnak S, Wurzer A, Schmidhammer H, Spetea M, Nazare M, Wolber G.   +10 more
europepmc   +1 more source

Fentanyl-Antibody Interaction as a Novel Strategy against Opiates and Opioids Abuse. [PDF]

J Med Chem
Ribaudo G, Taccani AA, Gianoncelli A.
europepmc   +1 more source

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol. [PDF]

Neuropsychopharmacology
van de Wetering R, Alder AF, Biggerstaff A, Sellen K, Luo D, Crowley RS, Prisinzano TE, Kivell BM.   +7 more
europepmc   +1 more source

Novel Application for G Protein-Biased Mu Opioid Receptor Agonists in Opioid Relapse Prevention. [PDF]

Biol Psychiatry, 2020
Fakira AK, Devi LA, Kennedy PJ.
europepmc   +1 more source

Effect of chronic delivery of the NOP/MOR partial agonist AT-201 and NOP antagonist J-113397 on heroin relapse in a rat model of opioid maintenance. [PDF]

Psychopharmacology (Berl)
Bossert JM, Caldwell KE, Korah H, Batista A, Bonbrest H, Fredriksson I, Jackson SN, Sulima A, Rice KC, Zaveri NT, Shaham Y.   +10 more
europepmc   +1 more source

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. [PDF]

Nature
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C.   +11 more
europepmc   +1 more source