Results 1 to 10 of about 5,661 (215)

Evaluating 5-nitrofurans as trypanocidal agents [PDF]

Antimicrobial Agents and Chemotherapy, 2013
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis.
Alvarez, G, Bot, C, Cerecetto, H, Di Maio, D, Gonzalez, M, Hall, BS, WILKINSON, SR   +6 more
core   +6 more sources

Evaluating 5-nitrothiazoles as trypanocidal agents [PDF]

Antimicrobial Agents and Chemotherapy, 2015
OA Monitor ExerciseOA Monitor ExerciseThe growth inhibitory properties of a 5-nitrothiazole series was evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency towards the parasite while exhibiting little ...
Aguilera-Venegas, B, O'Shea, IP, Shahed, M, WILKINSON, SR   +3 more
core   +6 more sources

DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. [PDF]

Antimicrob Agents Chemother, 2004
ABSTRACT The aromatic diamidines represent a class of compounds with broad-spectrum antimicrobial activity; however, their development is hindered by a lack of understanding of their mechanism of antimicrobial action. DB75 [2,5-bis(4-amidinophenyl)furan] is a trypanocidal aromatic diamidine that was originally developed as a ...
Lanteri CA, Trumpower BL, Tidwell RR, Meshnick SR.   +3 more
europepmc   +5 more sources

Gossypol: a potential trypanocidal agent [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1985
Antonio Blanco
doaj   +4 more sources

TcSR62, an RNA-binding protein, as a new potential target for anti-trypanocidal agents. [PDF]

Front Microbiol
Trypanosomatids are parasites of health importance that cause neglected diseases in humans and animals. Chagas’ disease, caused by Trypanosoma cruzi, affects 6–7 millions of people worldwide, mostly in Latin America, most of whom do not have access to diagnosis or treatment.
Níttolo AG, Chidichimo AM, Benacerraf AL, Cardozo T, Corso MC, Tekiel V, De Gaudenzi JG, Levy GV.   +7 more
europepmc   +6 more sources

Terpenoid Derivatives as Potential Trypanocidal Agents [PDF]

Medicinal chemistry, 2016
In this review we refer to a promising family of molecules in the fight against Chagas disease. Terpene derivatives are abundant in the plant Kingdom and in the last years many compounds have shown important biological activities. Diterpenes and sesquiterpene lactones have shown in vitro and in vivo trypanocidal activity and they emerge as potential ...
Esteban Lozano, Patricia Barrera
  +5 more sources

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

Frontiers in Medicine, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Chantal Reigada, Chantal Reigada, Melisa Sayé, Melisa Sayé, Otto Phanstiel, Edward Valera-Vera, Edward Valera-Vera, Mariana R. Miranda, Mariana R. Miranda, Claudio A. Pereira, Claudio A. Pereira   +10 more
doaj   +3 more sources

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

Heliyon, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Chantal Reigada, Melisa Sayé, Edward Valera-Vera, Mariana R. Miranda, Claudio A. Pereira   +4 more
doaj   +3 more sources

Synthesis of New Trypanocidal Agents from the Hybridisation of Metronidazole and Eugenol Analogues

Bioorganic Chemistry, 2023
Nitroimidazole compounds are well-known bioactive substances, and the structural activity relationship has been reported whereby the position of the nitro group within the imidazole ring has a large influence on the activity. This study focuses on synthesising new trypanocidal agents from the hybridisation of metronidazole with different natural ...
Lucas Lopardi Franco, Jamie Anthony Hawkes, Mônica Fraccarolli Pelozo, Cleydson Finotti Cordeiro, Letícia Fonseca Inácio, Rayssa de Cassia Alves Lemini, Elda Gonçalves Souza e. Leite, Stefânia Neiva Lavorato, Monique Dias Benedetti, Cristiane Alves Tulha, Rômulo Dias Novaes, Ivo Santana Caldas, Diogo Teixeira Carvalho   +12 more
  +5 more sources

Pilot-Scale Compound Screening against RNA Editing Identifies Trypanocidal Agents [PDF]

SLAS Discovery, 2014
Most mitochondrial messenger RNAs in trypanosomatid pathogens undergo a unique type of posttranscriptional modification involving insertion and/or deletion of uridylates. This process, RNA editing, is catalyzed by a multiprotein complex (~1.6 MDa), the editosome.
Houtan Moshiri, Vaibhav Mehta, Chun Wai Yip, Reza Salavati   +3 more
openalex   +3 more sources