Results 91 to 100 of about 5,661 (215)

Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs

ChemistrySelect, Volume 10, Issue 37, October 6, 2025.
Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández, Elia Guadalupe Jaimes‐Castelán, Ricardo Reyes‐Chilpa   +2 more
wiley   +1 more source

Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruzi.

PLoS ONE, 2016
Trypanosoma cruzi is the causative agent of Chagas' disease, which is a major endemic disease in Latin America and is recognized by the WHO as one of the 17 neglected tropical diseases in the world.
Valeria P Sülsen, Vanesa Puente, Daniela Papademetrio, Alcira Batlle, Virginia S Martino, Fernanda M Frank, María E Lombardo   +6 more
doaj   +1 more source

The silicon trypanosome [PDF]

, 2010
African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
BARBARA M. BAKKER, CHRISTINE CLAYTON, Duffieux, HANS V. WESTERHOFF, Hornberg, KEITH MATTHEWS, MARK GIROLAMI, MICHAEL P. BARRETT, PAUL A. M. MICHELS, R. LUISE KRAUTH-SIEGEL, RAINER BREITLING   +10 more
core   +4 more sources

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, Volume 32, Issue 5, Page 1495-1523, October 2025.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II

BMC Complementary Medicine and Therapies, 2021
Background Trypanosoma cruzi is the etiological agent of Chagas disease (CD) or American trypanosomiasis, an important public health problem in Latin America.
Marcella Paula Mansano Sarto, Hevillyn Fernanda Lucas da Silva, Nilma de Souza Fernandes, Ana Paula de Abreu, Gerson Zanusso Junior, Max Jean de Ornelas Toledo   +5 more
doaj   +1 more source

A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin [PDF]

FEBS Letters, 1998
African trypanosomes contain a cytosolic serine oligopeptidase, called OP‐Tb, that is reversibly inhibited by the active principles of three of the five most commonly used trypanocidal drugs: pentamidine, diminazene and suramin. OP‐Tb was inhibited by pentamidine in a competitive manner, and by suramin in a partial, non‐competitive manner.
Morty, Rory E., Troeberg, Linda, Pike, Robert N., Jones, Roy, Nickel, Peter, Lonsdale-Eccles, John D., Coetzer, Theresa H.T.   +6 more
openaire   +2 more sources

Improvement of colony management in insect mass‐rearing for sterile insect technique applications

Insect Science, Volume 32, Issue 5, Page 1476-1494, October 2025.
Abstract Sterile Insect Technique (SIT) applications against major insect pests and disease vectors rely on the cost‐effective production of high‐quality sterile males. This largely depends on the optimal management of target pest colonies by maximizing the benefits provided by a genetically rich and pathogen‐free mother colony, the presence of ...
Adly M.M. Abd‐Alla, Anne Geiger, David Haymer, Salvador Herrero, Johannes, A. Jehle, Fathiya Khamis, Pablo Liedo, Anna R. Malacrida, Flobert Njiokou, Thiago Mastrangelo, Soumaïla Pagabeleguem, Edwin M. Ramırez‐Santos, Vera I.D. Ros, Diego F. Segura, George Tsiamis, Brian L. Weiss   +16 more
wiley   +1 more source

In vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticles.

PLoS Neglected Tropical Diseases, 2014
The parasite Trypanosoma cruzi causes Chagas disease, which remains a serious public health concern and continues to victimize thousands of people, primarily in the poorest regions of Latin America.
Zumira A Carneiro, Pedro I da S Maia, Renata Sesti-Costa, Carla D Lopes, Tatiana A Pereira, Cristiane M Milanezi, Marcelo A Pereira da Silva, Renata F V Lopez, João S Silva, Victor M Deflon   +9 more
doaj   +1 more source

Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi. [PDF]

PLoS Neglected Tropical Diseases, 2017
Polyamines are essential compounds to all living organisms and in the specific case of Trypanosoma cruzi, the causative agent of Chagas disease, they are exclusively obtained through transport processes since this parasite is auxotrophic for polyamines ...
Chantal Reigada, Edward A Valera-Vera, Melisa Sayé, Andrea E Errasti, Carla C Avila, Mariana R Miranda, Claudio A Pereira   +6 more
doaj   +1 more source

The trypanocidal activity of the alkaloid oliverine involves inhibition of DNA synthesis [PDF]

, 2010
The Trypanosoma cruzi parasite is an etiologic agent of the American trypanosomiasis called Chagas disease. This pathology affects more than 24 million persons and represents one of the most important public health problems in Latin America.
Garro, Hugo Alejandro, Juri Ayub, Maximiliano, Lucero Estrada, Cecilia Stella Marys, Nieto, M., Pungitore, Carlos Rodolfo, Tonn, Carlos Eugenio   +5 more
core