Results 101 to 110 of about 5,661 (215)

Management of trypanosomiasis and leishmaniasis [PDF]

, 2012
<p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford, Alvar, Alvar, Barrett, Barrett, Ben Salah, Berman, Bern, Brun, Brun, Burri, Chappuis, Coura, Croft, Croft, El-Sayed, Frearson, Hailu, Jacobs, Jacobs, Le Loup, Lessa, M. P. Barrett, Miranda-Verastegui, Paine, Pinazo, Priotto, Rassi, Reithinger, Rodgers, S. L. Croft, Stuart, Sundar, Sundar, Sundar, Sundar, Torreele, Vanhollebeke, Vincent, Voogd   +39 more
core   +2 more sources

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study

Journal of the Brazilian Chemical Society, 2001
Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have been subjected to an interdisciplinary study since the seventies, when Dr. Benjamin Gilbert, at the Federal University of Rio de Janeiro, launched a program
De Moura Kelly C. G., Emery Flávio S., Neves-Pinto Cleverson, Pinto Maria do Carmo F. R., Dantas Andrea P., Salomão Kelly, Castro Solange L. de, Pinto Antônio V.   +7 more
doaj  

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Plumbagin, discovered in Plumbago zeylanica, has potential therapeutic effects such as anticancer, antimicrobial, and anti‐inflammatory characteristics. It has traditionally been used to treat anemia and rheumatic pain, but its therapeutic application is limited because of low bioavailability and toxicity risk factors.
Souparnika Thekkumkara, Arenbenla Longchar, Baskar Venkidasamy, Benod Kumar Kondapavuluri, Muthu Thiruvengadam, Mansour Ghorbanpour, Sathianarayanan Sankaran   +6 more
wiley   +1 more source

Aminoquinolone WR6026 as a feasible substitute for gentian violet in Chagas' disease prophylaxis in preserved blood for transfusional purposes

Revista da Sociedade Brasileira de Medicina Tropical, 2002
The search for a colorless, nontoxic and efficient drug to prevent transfusion-associated Chagas' disease (TACD) has been underway unsuccessfully since 1953 when gentian violet was preconized and to date is still being used as the only in vitro ...
Moraes-Souza Helio, Pianetti Gisele Marilia, Barretto Orlando César de Oliveira Pereira, Nonoyama Kimyo, Grolg M., Chiari Egler   +5 more
doaj  

Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani. Preliminary in silico ADMET studies of 5-nitroimidazole derivatives

European Journal of Medicinal Chemistry Reports
The synthesis and evaluation of the biological activity of a series of 5-nitroimidazole hybrids is described. The structures of the synthesized hybrids were confirmed by spectral analysis FT-IR, 1H NMR, 13C NMR, MS, and by Elemental Analysis.
Miguel A. Rodríguez, Ali Mijoba, Nereida J. Parra-Giménez, Zuleyma Blanco, Katiuska Chávez, Alirica I. Suárez, Esteban Fernandez-Moreira, Hegira Ramírez, Jaime E. Charris   +8 more
doaj   +1 more source

Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease

Parasites & Vectors, 2011
Background Chagas disease is a health threat for many people, mostly those living in Latin America. One of the most important problems in treatment is the limitation of existing drugs.
Triana Omar, Maya Juan D, Echeverri Fernando, Baquero Eduard, Genes Carlos   +4 more
doaj   +1 more source

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND:Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves.
Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust   +12 more
doaj   +1 more source

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. [PDF]

, 2014
The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the world's major neglected infections. Although development of improved antiparasitic drugs is considered a priority, there have been no significant treatment advances in ...
Francisco, Amanda Fortes, Kelly, John M, Lewis, Michael D, Taylor, Martin C   +3 more
core   +1 more source

Selective Antiproliferative and Apoptotic Effects of 2,6‐Diketopiperazines on MDA‐MB‐231 Triple‐Negative Breast Cancer

Chemical Biology &Drug Design, Volume 105, Issue 4, April 2025.
ABSTRACT Diketopiperazines (DKPs) have emerged as promising candidates for treating diverse diseases, particularly cancer. In this context, 2,5‐diketopiperazines have been extensively investigated in comparison with 2,6‐diketopiperazines. This work explores the selectivity and impact of 2,6‐diketopiperazine enantiomers derived from α‐amino acids on MDA‐
Flor Paulina Garrido González, Martha Edith Macías Pérez, Octavio Rodríguez Cortés, Elvia Mera Jiménez, Teresa Mancilla Percino   +4 more
wiley   +1 more source