Results 111 to 120 of about 5,661 (215)

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Docking simulation between HIV peptidase inhibitors and Trypanosoma cruzi aspartyl peptidase

BMC Research Notes, 2018
Objective The low investment in research, diagnosis and treatment are factors that contribute to the continuity of Chagas’ disease as a neglected tropical diseases (NTDs).
Vanessa V. S. Castilho, Keyla C. S. Gonçalves, Karina M. Rebello, Luiz P. R. Baptista, Leandro S. Sangenito, Helena L. C. Santos, Marta H. Branquinha, André L. S. Santos, Rubem F. S. Menna-Barreto, Ana C. Guimarães, Claudia M. d’Avila-Levy   +10 more
doaj   +1 more source

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]

, 2017
Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam, Horn, David, Konno, Aya, Kumar, Ambika, Meredith, Emma Louise, Seifert, Karin, Szular, Joanna, Wilkinson, Shane R.   +7 more
core   +4 more sources

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Cymantrene–Triazole "Click" Products: Structural Characterization and Electrochemical Properties [PDF]

, 2014
We report the first known examples of triazole-derivatized cymantrene complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I), obtained via a “click” chemical synthesis, bearing a phenyl, 3-aminophenyl, or 4-aminophenyl moiety ...
Abboud J.-L. M., Anderson C. B., Astruc D., Badèche S., Baltz T., Beyer B., Bock V. D., Borissova A. O., Calladine J. A., Carvalho I., Chong D., Clough M. C., Dallagi T., David P. Day, David. L. Hughes, Dietmar Steverding, Evrard D., Geiger W. E., Geiger W. E., Gil M. V., Glans L., Gregory G. Wildgoose, Gritzner G., Happ B., Hirano T., Hirumi H., Holovics T. C., Huber W., Huisgen R., Jaschinski T., Kee J. W., Kilpin K. J., Kolb H. C., Kolb H. C., Lage M. L., Lawrence E. J., Laws D. R., Laws D. R., Leroux Y. R., Leroux Y. R., Liu Y., Lunquist R. T., Ornelas C., Ornelas C., Otón F., Otón F., Rapakousiou A., Romero T., Romero T., Romero T., Schweinfurth D., Schweinfurth D., Schweinfurth D., Sheridan M. V., Steverding D., Sünkel K., Thomas Dann, To T. T., Vasily S. Oganesyan, Yoo E. J.   +59 more
core   +1 more source

The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi, Federico Ladu, Fabrizio Carta, Claudiu T. Supuran   +3 more
wiley   +1 more source

Nutritional, Nutraceutical, and Medicinal Potential of Cantharellus cibarius Fr.: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
This review explores the nutritional, nutraceutical, and medicinal potential of Cantharellus cibarius, known as the “Golden chanterelle.” Emphasizing its rich composition of bioactive compounds and wide range of health benefits, the review also covers ecological significance, preservation strategies, and potential applications in dietary supplements ...
Ajay Kumar, Reema Devi, Rajni Dhalaria, Ashwani Tapwal, Rachna Verma, Summya Rashid, Gehan M. Elossaily, Khalid Ali Khan, Kow‐Tong Chen, Tarun Verma   +9 more
wiley   +1 more source

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine [PDF]

, 2017
Sleeping sickness is an infectious disease that is caused by the protozoan parasite Trypanosoma brucei. The second stage of the disease is characterised by the parasites entering the brain.
Rushworth, Stuart A., Steverding, Dietmar   +1 more
core   +1 more source

An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase

International Journal for Parasitology: Drugs and Drug Resistance, 2015
In order to identify new compounds to treat Chagas disease during the acute phase with higher activity and lower toxicity than the reference drug benznidazole (Bz), two hydroxyphthalazine derivative compounds were prepared and their trypanocidal effects ...
Francisco Olmo, Kristína Urbanová, Maria Jose Rosales, Ruben Martín-Escolano, Manuel Sánchez-Moreno, Clotilde Marín   +5 more
doaj   +1 more source

Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana [PDF]

, 2013
Leishmaniasis is a worldwide parasitic disease, caused by monoflagellate parasites of the genus Leishmania. In the search for more effective agents against these parasites, the identification of molecular targets has been attempted to ensure the ...
Barrera, Patricia Andrea, Beer, Maria Florencia, Lozano, Esteban Sebastián, Martino, Virginia Susana, Rivera, Monica Raquel, Sosa Escudero, Miguel Angel, Sülsen, Valeria Patricia, Tonn, Carlos Eugenio   +7 more
core   +3 more sources