Results 131 to 140 of about 5,661 (215)

Global Health Priority Box: Discovering Flucofuron as a Promising Antikinetoplastid Compound

Pharmaceuticals
Leishmaniasis, produced by Leishmania spp., and Chagas disease, produced by Trypanosoma cruzi, affect millions of people around the world. The treatments for these pathologies are not entirely effective and produce some side effects.
Carlos J. Bethencourt-Estrella, Atteneri López-Arencibia, Jacob Lorenzo-Morales, José E. Piñero   +3 more
doaj   +1 more source

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei [PDF]

, 2013
Víctor M. Castillo‐Acosta, Antonio E. Vidal, Luis M. Ruiz‐Pérez, Els J. M. Van Damme, Yasuhiro Igarashi, Jan Balzarini, Dolores González‐Pacanowska   +6 more
openalex   +1 more source

Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins [PDF]

, 2017
Cyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported the in vitro anti-Trypanosoma cruzi activity of H-7-94 and F-7-62 non-immunosuppressive CsA analogues.
BÚA, J., DUBIN, M., FICHERA, L.E., FUCHS, A.G., MORETTI, G., POTENZA, M., RUIZ, A.M., SCABONE, C.M., WENGER, R.O.   +8 more
core  

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Új kéntartalmú szénhidrát-származékok trypanosoma- ill. amöba-ellenes hatásának vizsgálata: szerkezet-hatás összefüggések = Testing the trypanocidal, amoebicidal activity of novel S-containing sugar derivatives: structure – activity investigations. [PDF]

, 2011
A Trypanosoma cruzi protozoa, a Chagas betegség kórokozója, Latin Amerikában évente 12-14 millió ember fertőzéséért felelős. A betegség kezelésére jelenleg alkalmazott szerek hatásossága nem kielégítő, különösen a betegség gyakori, krónikus formája ellen.
E. Kövér, Katalin, Illyés, Tünde Zita, Szilágyi, László   +2 more
core  

[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].

Revista Argentina de microbiologia, 1989
Incubation of Trypanosoma cruzi culture (epimastigote) forms with nifurtimox (10 or 100 microM), benznidazole (38 or 380 microM) and beta-lapachone (1.6 or 7.8 microM) produced damage of nuclear DNA, as shown by the increased rate of the "unscheduled DNA synthesis" in epimastigotes arrested at phase S (9-, 3-, and 6-fold, respectively). alpha-lapachone,
S G, Goijman, A C, Frasch, A O, Stoppani
openaire   +1 more source

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

, 2001
Zhili Li, Michael W. Fennie, Bruce Ganem, Matthew T Hancock, Muris Kobašlija, Donna Rattendi, Cyrus J. Bacchi, Mary C. O’Sullivan   +7 more
openalex   +1 more source

Genotoxicity assessment of four novel quinazoline-derived trypanocidal agents in the Drosophila wing somatic mutation and recombination test [PDF]

, 2019
Luis Felipe Santos-Cruz, Bertha Guadalupe Ramírez-Cruz, Miguel García-Salomé, Zaira Yuriria Olvera-Romero, Francisco Hernández‐Luis, Luis Barbo Hernández‐Portilla, Ángel Durán-Díaz, Irma Elena Dueñas-García, Laura Castañeda-Partida, Elías Piedra‐Ibarra, César Mendoza-Martínez, María Eugenia Heres-Pulido   +11 more
openalex   +1 more source

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei [PDF]

, 2015
Ali, S, Helsby, NA, Hu, L, Hussein, I, Kumar, A, Meredith, EL, Sarkar, H, Sullivan, JA, Tong, JL, Wilkinson, SR, Wong, M, Zaman, I   +11 more
core   +1 more source

Molecular Docking-Based Virtual Screening of FDA-Approved Drugs Using Trypanothione Reductase Identified New Trypanocidal Agents [PDF]

Rogelio Gómez-Escobedo, Domingo Méndez-Álvarez, Citlali Vázquez, Emma Saavedra, Karina Vázquez, Verónica Alcántara‐Farfán, Joaquin Cordero‐Martínez, Alonzo González‐González, Gildardo Rivera, Benjamín Nogueda‐Torres   +9 more
openalex   +1 more source