Results 201 to 210 of about 5,661 (215)

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents

Bioorganic & Medicinal Chemistry Letters, 2006
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b.
Julieta, Coro, Richard, Atherton, Susan, Little, Hayley, Wharton, Vanessa, Yardley, Amaury, Alvarez, Margarita, Súarez, Rolando, Pérez, Hortensia, Rodríguez   +8 more
openaire   +2 more sources

Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents

Journal of Medicinal Chemistry, 1990
Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines, were synthesized and evaluated for antineoplastic and trypanocidal activities in mice. 1-Methyl-1,2,2-tris(methylsulfonyl)hydrazine emerged as an extremely efficacious antitrypanosomal agent, whereas 1-(2-chloroethyl)-1,2,2-tris(methylsulfonyl)hydrazine was ...
K, Shyam, P G, Penketh, A A, Divo, R H, Loomis, C L, Patton, A C, Sartorelli   +5 more
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Photosensitization by the trypanocidal agent crystal violet. Type i versus type II reactions

Chemico-Biological Interactions, 1986
The photoreduction of crystal violet to a carbon-centered radical was detected directly by electron spin resonance (ESR) spectroscopy under anaerobic conditions. The linewidth (0.9 G) of this radical was less broad than the linewidth (11.0 G) of the free radical obtained in Trypanosoma cruzi incubations.
K, Reszka, F S, Cruz, R, Docampo
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Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation

European Journal of Medicinal Chemistry, 2019
The available drugs for treating Leishmaniasis and American trypanosomiasis have high toxicity and multiple side effects, among other problems. More effective and less toxic treatments are urgently needed. A series of chalcones that contained a prenyloxy or geranyloxy substituent was synthesized and characterized. Each substituent was attached to the A
José C. Espinoza-Hicks, Karla Fabiola Chacón-Vargas, Jessica L. Hernández-Rivera, Benjamín Nogueda-Torres, Joaquín Tamariz, Luvia Enid Sánchez-Torres, Alejandro Camacho-Dávila   +6 more
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ChemInform Abstract: Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gladys E. Granero, Maria M. de Bertorello, Margarita C. Brinon   +2 more
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Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium

Analytical and Bioanalytical Chemistry, 2014
The chromatographic isolation and characterisation of the four compounds present in the quaternary phenanthridine veterinary trypanocidal agent, isometamidium chloride hydrochloride (ISM), is reported. The isolated compounds were unambiguously characterised using spectroscopic (NMR, UV, IR and MS) methods as 3-amino-8-[3-(3-carbamimidoyl-phenyl ...
John O, Igoli, Gavin, Blackburn, Alexander I, Gray, Oliver B, Sutcliffe, David G, Watson, Melvin R, Euerby, Graham G, Skellern   +6 more
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Novel fluorinated quaternary ammonium salts and their in vitro activity as trypanocidal agents

Medicinal Chemistry Research, 2019
As the impact of aromatic rings and fluorine substituents in commercial drugs is attributed to their electronic distribution and structure rigidity that determine metabolic stability and toxicity, 30 quaternary ammonium salts (QAS) of the form [X-CH2N(CH3)2(CH2)nCH = C(Ar2)]+I− (where X=H, Cl or I, n = 2 or 3, and Ar = m-C6H4CF3, p-C6H4CF3, m-C6H4F, p ...
Marisol López-Muñoz, Jessica Johanna Gomez-Peña, Luz Amalia Ríos-Vásquez, Rogelio Ocampo-Cardona, Marjorie A. Jones, Craig S. Haynes, Craig Wallace, Sara M. Robledo   +7 more
openaire   +1 more source

The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes

Chemico-Biological Interactions, 2003
This study has investigated the effect of phenobarbitone (PB), 3-methylcholanthrene (3-MC), and deltamethrin (DM) on the metabolism of two trypanocidal diamidines; pentamidine isethionate and diminazene aceturate in freshly isolated Sprague-Dawley rat hepatocytes.
Atsriku, C., Skellern, G.G., Grant, M.H., Watson, D.G.   +3 more
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Influence of Pentamidine and Two New Trypanocidal Agents (DAPI, DIPI) on Liver Metabolism of Mice

Pharmacology & Toxicology, 1991
Abstract:The effects of equimolar doses (65.5 μmol/kg intraperitoneally) of three trypanocidal compounds, i.e. pentamidine, 6‐amidino‐2‐(amidinophenyl)indole (DAPI), and 6‐imidazolino‐2‐(imidazolinophenyl)indole (DIPI) on some parameters of liver carbohydrate, lipid and energy metabolism have been assessed in male NMRI mice. Most prominent effects were
H, Sippel, U, Steinmann, C J, Estler
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[Plasma kinetics of a spiroarsorane trypanocidal agent in sheep trypanosomiasis].

Bulletin de la Societe de pathologie exotique (1990), 1990
In a previous study, spiroarsoranes were very effective against both the two pathogenic phases of the experimental sheep trypanosomiasis. In this paper, the authors had studied the plasmatic pharmacokinetics of these compounds. Data had shown one peak 10 min after injection of a 3 months inoculated sheep, and 90 min for the control sheep. Spiroarsorane
G, Dreyfuss, B, Penicaut, J G, Wolf, G, Dubost, J A, Nicolas   +4 more
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