Natural Sesquiterpene Lactones as Potential Trypanocidal Therapeutic Agents: A Review [PDF]
Natural Product Communications, 2016 Chagas’ disease and Human African Trypanosomiasis are parasitic diseases that remain major health problems, mainly among the poorest and the most marginalized communities from Latin America and Africa. The scarcity of effective chemotherapy, due to the low investment in the research and development (R&D) of new drugs, together with a high ...
Liliana Muschietti, Jerónimo Ulloa
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The trans-Sialidase from Trypanosoma cruzi a Putative Target for Trypanocidal Agents [PDF]
The Open Parasitology Journal, 2010 Trypanosomatid protozoa are parasites of considerable medical and economical importance because they are the causative agents of chronic human and livestock diseases endemic in developing countries. Trypanosoma cruzi is the causative agent of Chagas´ disease, present in most of Latin America. The biology of this parasite presents some unusual features,
Lúcia Mendonça‐Previato +3 more
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Quinol derivatives as potential trypanocidal agents
Bioorganic & Medicinal Chemistry, 2011 Quinols have been developed as a class of potential anti-cancer compounds. They are thought to act as double Michael acceptors, forming two covalent bonds to their target protein(s). Quinols have also been shown to have activity against the parasite Trypanosoma brucei, the causative organism of human African trypanosomiasis, but they demonstrated ...
Amy S. Capes +10 more
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Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents [PDF]
Journal of Chemical Research, 1999 The synthesis of three new isoxazolylnaphthoquinones with an ethyl group on the isoxazole ring is reported.
Gladys E. Granero +2 more
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Evaluating the influence of trypanosomiasis on murine model using Corchorus olitorius leaf extract as a trypanocidal agent [PDF]
Bulletin of Natural Sciences ResearchTrypanosomiasis, a parasitic disease caused by trypanosomes, which are flagellate protozoa transmitted through the bite of the tsetse fly, manifests with symptoms including substantial weight loss, anemia, fever, edema, adenitis, dermatitis, and nervous ...
Madaki Fatima M. +4 more
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Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporter. [PDF]
PLoS ONE, 2014 Trypanosoma cruzi, the etiological agent of Chagas' disease, has a metabolism largely based on the consumption of glucose and proline. This amino acid is essential for host cells infection and intracellular differentiation.
Melisa Sayé +4 more
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Synthesis of Novel Acetamidobenzanilides Derivatives as Potencial Trypanocidal Agents [PDF]
Abstract A simple synthesis of novel N-(2-[N’-acetamidomethyl])benzanilides derivatives from 2-nitrobenzaldehyde in a four steps process is described. The 1H-NMR and 13C-NMR spectra were meticulously analyzed to characterize their structure and it was observed that derivatives with an ortho-substituted phenyl group exhibited detectable ...
Valentín I. Ortellado +9 more
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Insights from aquaporin structures into drug-resistant sleeping sickness [PDF]
eLifeTrypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world.
Modestas Matusevicius +22 more
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Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents
Arabian Journal of Chemistry, 2021 Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. Therefore, the search for alternative therapeutic solutions is urgent.
Francisco Salgado +10 more
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New insights into the pro-oxidant mechanism of dehydroleucodine on Trypanosoma cruzi [PDF]
Scientific ReportsChagas disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most important neglected diseases in Latin America. The limited use of the current nitro-derivative-based chemotherapy highlights the need for alternative drugs and the identification ...
Jessica Gomez +10 more
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