Results 31 to 40 of about 5,661 (215)

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +32 more sources

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent. [PDF]

Chem Biodivers
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Oliveira ND, Pagotti MC, Paula LAL, Paixão MZ, Albino Dos Santos D, de Freitas RF, Ambrósio SR, Veneziani RCS, Bastos JK, Magalhães LG.   +9 more
europepmc   +2 more sources

Natural and Bioinspired Lipidic Alkynylcarbinols as Leishmanicidal, Antiplasmodial, Trypanocidal, Fungicidal, Antibacterial, and Antimycobacterial Agents

Journal of Natural Products
The present review article recapitulates for the first time the antipathogenic biological data of a series of lipidic natural products and synthetic analogues thereof characterized by the presence in their structure of an alkynylcarbinol unit. The cytotoxic properties of such natural and bioinspired compounds have been covered by several literature ...
J P Bouvet, Valérie Maraval, Stéphanie Ballereau, Vania Bernardes‐Génisson, Yves Génisson   +4 more
openalex   +4 more sources

SYNTHESIS OF 4-ALKYLAMINO-6-CHLOROQUINOLINES AS POTENTIAL TRYPANOCIDAL AGENTS [PDF]

Heterocyclic Communications, 2002
Ricardo A. Tapia, Yolanda Prieto, Jaime A. Valderrama, Alain Fournet, Antonieta Rojas de Árias, Héctor Nakayama, Susana Torres   +6 more
openalex   +4 more sources

Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

Chemical Communications, 2018
C–H oxygenation of quinones by weak O-coordination was achieved by versatile ruthenium(ii) catalysis with ample substrate scope and trypanocidal compounds were also identified.
Gleiston G. Dias, Torben Rogge, Rositha Kuniyil, Claus Jacob, Rubem F. S. Menna‐Barreto, Eufrânio N. da Silva Júnior, Lutz Ackermann   +6 more
openalex   +5 more sources

Cutaneous reactions during treatment with Nifurtimox or Benznidazole among Trypanosoma cruzi seropositive adults without symptomatic cardiomyopathy: A safety sub analysis of a placebo-controlled randomised trial. [PDF]

Trop Med Int Health
Abstract Objectives To determine, in a randomised placebo‐controlled trial, if cutaneous adverse reactions during treatment (CARDT) with Benznidazole occur as often as with Nifurtimox, and whether the dose and duration of treatment change that frequency.
Villar JC, Saavedra MF, Bermúdez PA, Herrera EV, Vásquez SM, Arango H, Camacho A, Olivera MJ.   +7 more
europepmc   +2 more sources

Tris(3-methoxypropyl)tin aminobenzoates as potentially trypanocidal agent

, 2004
A set of tris(3-methoxypropyl)tin aminobenzoates and N-(4,6-diamino-1,3,5-triazin-2-yl-)aminobenzoates as compounds with potential trypanocidal activity have been prepared and their solubility in water was determined. On the basis of their 13C and 119Sn NMR spectra and IR spectra, bonding relations in these esters are discussed and a model of the ...
Lenka Semenyšínová, Karel Handlíř
openalex   +2 more sources

Piplartine Synthetic Analogs: In Silico Analysis and Antiparasitic Study against Trypanosoma cruzi

Applied Sciences, 2023
Neglected tropical diseases (NTDs) cause thousands of deaths each year. Among these diseases, we find Chagas disease, whose etiologic agent is Trypanosoma cruzi.
Rayanne H. N. Silva, Emanuel P. Magalhães, Rebeca C. Gomes, Yunierkis Perez-Castillo, Alice M. C. Martins, Damião P. de Sousa   +5 more
doaj   +1 more source

A Trypsin Inhibitor from Moringa oleifera Flowers Modulates the Immune Response In Vitro of Trypanosoma cruzi-Infected Human Cells

Antibiotics, 2020
Trypanosoma cruzi causes the lethal Chagas disease, which is endemic in Latin America. Flowers of Moringa oleifera (Moringaceae) express a trypsin inhibitor (MoFTI) whose toxicity to T. cruzi trypomastigotes was previously reported.
Isabella Coimbra Vila Nova, Leyllane Rafael Moreira, Diego José Lira Torres, Kamila Kássia dos Santos Oliveira, Leydianne Leite de Siqueira Patriota, Luana Cassandra Breitenbach Barroso Coelho, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão, Virgínia Maria Barros de Lorena, Emmanuel Viana Pontual   +9 more
doaj   +1 more source

Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease (CD), a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, is an important public health problem mainly in Latin America, leading to approximately 12,000 annual deaths.
Juliana Magalhães Chaves Barbosa, Yasmin Pedra-Rezende, Luíza Dantas Pereira, Tatiana Galvão de Melo, Helene Santos Barbosa, Joseli Lannes-Vieira, Solange Lisboa de Castro, Anissa Daliry, Kelly Salomão   +8 more
doaj   +1 more source