Results 41 to 50 of about 5,661 (215)

Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. [PDF]

PLoS Neglected Tropical Diseases, 2013
A multi-step cascade strategy using integrated ligand- and target-based virtual screening methods was developed to select a small number of compounds from the ZINC database to be evaluated for trypanocidal activity.
Helton J Wiggers, Josmar R Rocha, William B Fernandes, Renata Sesti-Costa, Zumira A Carneiro, Juliana Cheleski, Albérico B F da Silva, Luiz Juliano, Maria H S Cezari, João S Silva, James H McKerrow, Carlos A Montanari   +11 more
doaj   +1 more source

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Frontiers in Tropical Diseases, 2023
The repurposing of approved drugs is an appealing method to fast-track the development of novel therapies for neglected diseases. Amiodarone and dronedarone, two approved antiarrhythmic agents, have been reported to have potential for the management of ...
Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain   +16 more
doaj   +1 more source

Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study [PDF]

Current Pharmaceutical Design, 2020
In this report, we extend the SAR analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of Trypanosoma brucei and Trypanosoma cruzi. Sleeping sickness and Chagas disease, caused by the tropical parasites T. brucei and T.
Vasiliki Pardali, Erofili Giannakopoulou, Dimitrios-Ilias Balourdas, Vassilios Myrianthopoulos, Martin C. Taylor, Marina Šekutor, Kata Mlinarić-Majerski, John M. Kelly, Grigoris Zoidis   +8 more
openaire   +3 more sources

Treatment of T. cruzi infected human platelet concentrates with aminomethyltrimethyl psoralen (AMT) and ultravioleta (UV-A) light: preliminary results

Revista da Sociedade Brasileira de Medicina Tropical, 1996
The present measures adopted to prevent transfusion-associated Chagas' disease include screening of blood donors. and/or the inactivation of T. cruzi in collected blood using gentian violet (GV) as a trypanocidal agent. In this study, we investigated the
Hélio Moraes-Souza, José Orlando Bordin, Leslie Bardossy, Morris A. Blajchman   +3 more
doaj   +3 more sources

Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Marine Drugs, 2013
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Orazio Taglialatela-Scafati, Deniz Tasdemir, Marcel Kaiser, Henny A. Dien, Barbara Calcinai, Carlo Cerrano, Fernando Scala, Giuseppina Chianese   +7 more
doaj   +1 more source

Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei.

PLoS Neglected Tropical Diseases, 2020
Amino acid metabolism within Trypanosoma brucei, the causative agent of human African trypanosomiasis, is critical for parasite survival and virulence. Of these metabolic processes, the transamination of aromatic amino acids is one of the most important.
Peter E Cockram, Emily A Dickie, Michael P Barrett, Terry K Smith   +3 more
doaj   +1 more source

Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:The obligate intracellular protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a neglected illness affecting millions of people in Latin America that recently entered non-endemic countries through immigration, as a ...
Giselle Villa Flor Brunoro, Vitor Marcel Faça, Marcelle Almeida Caminha, André Teixeira da Silva Ferreira, Monique Trugilho, Kelly Cristina Gallan de Moura, Jonas Perales, Richard Hemmi Valente, Rubem Figueiredo Sadok Menna-Barreto   +8 more
doaj   +1 more source

Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure [PDF]

, 2018
Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects.
Benaim, Gustavo, Hejchman, Elżbieta, Hernández Rodríguez, Vanessa, Pinto Martinez, Andrea, Rodríguez Durán, Jessica Jenireth   +4 more
core   +1 more source

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]

, 2018
Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P., Begolo, Daniela, Bengaly, Zakaria, Clayton, Christine, Freund, Yvonne, Gillingwater, Kirsten, Giordani, Federica, Pöhner, Ina, Rowan, Timothy G., Vincent, Isabel M., Wade, Rebecca C., Witty, Michael J.   +11 more
core   +3 more sources

Trypanosoma brucei: trypanocidal and cell swelling activities of lasalocid acid [PDF]

, 2017
Chemotherapeutic treatment of human and animal trypanosomaisis is unsatisfactory because only a few drugs are available. As these drugs have poor efficacy and cause adverse reactions, more effective and tolerable medications are needed.
Huczyński, Adam, Steverding, Dietmar
core   +1 more source