Likely Autochthonous Transmission of Trypanosoma cruzi to Humans, South Central Texas, USA
Chagas disease, caused by Trypanosoma cruzi, is a major neglected tropical disease affecting the Americas. The epidemiology of this disease in the United States is incomplete.
S. Gunter+10 more
semanticscholar +1 more source
Genomic stress in diseases stemming from defects in the second brain
The enteric nervous system, a.k.a., second brain, is subject to a range of genotoxic exposures that include intrinsic oxidative stress and extrinsic agents associated with ingested foods, inflammation, and dysbiosis. Resulting DNA damage, if left unrepaired, can induce cell dysfunction or death, resulting in gut abnormalities and enteric neuropathy ...
Lobke Marie M. Mombeek+2 more
wiley +1 more source
As características físico-geográficas da região Ciénega, Jalisco, México a tornam propícia para transmissão do Trypanosoma cruzi, causador da doença de Chagas.
César Gómez-Hernández+5 more
doaj +1 more source
Genome and transcriptome studies of the protozoan parasites Trypanosoma cruzi and Giardia intestinalis [PDF]
Trypanosoma cruzi and Giardia intestinalis are two human pathogens and protozoan parasites responsible for the diseases Chagas disease and giardiasis, respectively. Both diseases cause suffering and illness in several million individuals. The former disease occurs primarily in South America and Central America, and the latter disease occurs worldwide ...
arxiv
Discrete typing units of Trypanosoma cruzi identified in rural dogs and cats in the humid Argentinean Chaco [PDF]
The discrete typing units (DTUs) of Trypanosoma cruzi that infect domestic dogs and cats have rarely been studied. With this purpose we conducted a cross-sectional xenodiagnostic survey of dog and cat populations residing in 2 infested rural villages in ...
Cardinal, Marta Victoria+5 more
core +1 more source
Bacterial Outer Membrane Vesicles: From Physics to Clinical
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou+7 more
wiley +1 more source
INTRODUCTION: For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological ...
César Gómez-Hernández+8 more
doaj +1 more source
Examining marginal sequence similarities between bacterial type III secretion system and Trypanosoma cruzi surface proteins: Horizontal gene transfer or convergent evolution? [PDF]
The cell invasion mechanism of Trypanosoma cruzi has similarities with some intracellular bacterial taxa especially regarding calcium mobilization. This mechanism is not observed in other trypanosomatids, suggesting that the molecules involved in this type of cell invasion were a product of (1) acquired by horizontal gene transfer; (2) secondary loss ...
arxiv
Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages
Background During Trypanosoma cruzi infection, macrophages produce reactive oxygen species (ROS) in a process called respiratory burst. Several works have aimed to elucidate the role of ROS during T. cruzi infection and the results obtained are sometimes
G. R. Goes+5 more
semanticscholar +1 more source
Structure and inhibition of diaminopimelic acid epimerase by slow‐binding α‐methyl amino acids
Abstract Cofactor‐independent racemases and epimerases produce D‐amino acids from their L‐isomers for a variety of biological processes. These enzymes operate via an unusual mechanism that relies on an active site cysteine thiolate (pKa ~ 8.5) to deprotonate an amino acid α‐carbon (pKa ~ 29) and are of interest not only because of their biocatalytic ...
Tess Lamer+8 more
wiley +1 more source